XB-ART-46557
Chromosoma
2009 Oct 01;1185:549-65. doi: 10.1007/s00412-009-0221-9.
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DNA methylation and methyl-CpG binding proteins: developmental requirements and function.
Bogdanović O
,
Veenstra GJ
.
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DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and approximately 60% to 90% of these dinucleotides are modified. Distinct DNA methylation patterns, which can vary between different tissues and developmental stages, exist on specific loci. Sites of DNA methylation are occupied by various proteins, including methyl-CpG binding domain (MBD) proteins which recruit the enzymatic machinery to establish silent chromatin. Mutations in the MBD family member MeCP2 are the cause of Rett syndrome, a severe neurodevelopmental disorder, whereas other MBDs are known to bind sites of hypermethylation in human cancer cell lines. Here, we review the advances in our understanding of the function of DNA methylation, DNA methyltransferases, and methyl-CpG binding proteins in vertebrate embryonic development. MBDs function in transcriptional repression and long-range interactions in chromatin and also appear to play a role in genomic stability, neural signaling, and transcriptional activation. DNA methylation makes an essential and versatile epigenetic contribution to genome integrity and function.
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???displayArticle.link??? Chromosoma
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R01 HD054356-04 NICHD NIH HHS
Species referenced: Xenopus
Genes referenced: mbd1 mbd2 mbd3 mbd4 mecp2 zbtb33 zbtb38
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Fig. 1. Two families of proteins that bind methylated DNA. a Methyl-CpG binding proteins (MBDs): MBD proteins display homology within their MBD domains, while the transcription repression domains (TRD) described for MeCP2, MBD1, and MBD2 are non-homologous. In addition to its MBD domain, MBD1 is able to bind unmethylated DNA via its third CxxC zinc-finger motif. MBD2 features a characteristic stretch of glycine and arginine residues (GR) and has juxtaposed MBD and TRD domains. MBD3 is, due to a mutation in the MBD domain, not able to bind methylated CpGs in mammals. MBD4, a thymine glycosylase, contains a C-terminal glycosylase domain used for excision-based DNA repair. b Kaiso protein family: three members of the Kaiso protein family have been described so far. Kaiso, ZBTB4, and ZBTB38 share a triple zinc-finger domain and a BTB/POZ domain which in case of ZBTB4 contains a 60 amino acid insertion. Furthermore, ZBTB4 and ZBTB38 contain respectively three and seven additional zinc-fingers |
References [+] :
Aapola,
Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
2000, Pubmed
Aapola, Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. 2000, Pubmed
Aapola, Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. 2002, Pubmed
Adams, Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2. 2007, Pubmed
Agarwal, MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. 2007, Pubmed
Amir, Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. 1999, Pubmed
An, Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. 2008, Pubmed
Angrisano, TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. 2006, Pubmed
Antequera, DNA methylation in the fungi. 1984, Pubmed
Arita, Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. 2008, Pubmed
Avvakumov, Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. 2008, Pubmed
Ballas, REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. 2005, Pubmed
Ballestar, Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. 2003, Pubmed
Barchuk, Molecular determinants of caste differentiation in the highly eusocial honeybee Apis mellifera. 2007, Pubmed
Barr, Mbd2 contributes to DNA methylation-directed repression of the Xist gene. 2007, Pubmed
Barreto, Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. 2007, Pubmed , Xenbase
Bartkuhn, Long range chromatin interactions involved in gene regulation. 2008, Pubmed
Bellacosa, MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. 1999, Pubmed
Bestor, Creation of genomic methylation patterns. 1996, Pubmed
Bhattacharya, A mammalian protein with specific demethylase activity for mCpG DNA. 1999, Pubmed
Bibikova, High-throughput DNA methylation profiling using universal bead arrays. 2006, Pubmed
Bibikova, Human embryonic stem cells have a unique epigenetic signature. 2006, Pubmed
Bird, DNA methylation patterns and epigenetic memory. 2002, Pubmed
Bird, DNA methylation and the frequency of CpG in animal DNA. 1980, Pubmed
Bird, CpG-rich islands and the function of DNA methylation. , Pubmed
Bittel, Prader-Willi syndrome: clinical genetics, cytogenetics and molecular biology. 2005, Pubmed
Boeke, The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A. 2000, Pubmed
Bourc'his, Dnmt3L and the establishment of maternal genomic imprints. 2001, Pubmed
Brackertz, Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. 2002, Pubmed , Xenbase
Brown, DNA demethylation induced by the methyl-CpG-binding domain protein MBD3. 2008, Pubmed
Brunner, Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. 2009, Pubmed
Campanero, CpG methylation as a mechanism for the regulation of E2F activity. 2000, Pubmed
Campbell, Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo. 2004, Pubmed
Chabot, The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle. 1995, Pubmed
Chadwick, MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein? 2007, Pubmed
Chahrour, MeCP2, a key contributor to neurological disease, activates and represses transcription. 2008, Pubmed
Chang, The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. 2006, Pubmed
Chen, Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 2003, Pubmed
Chen, Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. 2001, Pubmed
Clouaire, Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin? 2008, Pubmed
COLHOUN, Neurohormonal properties of royal jelly. 1960, Pubmed
Collins, Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. 2004, Pubmed
Daniel, The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. 2002, Pubmed
Daniel, The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. 1999, Pubmed
Davis, Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation. 2001, Pubmed , Xenbase
Dean, Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. 2001, Pubmed
Delaval, Epigenetic regulation of mammalian genomic imprinting. 2004, Pubmed
Denslow, The human Mi-2/NuRD complex and gene regulation. 2007, Pubmed
Deplus, Dnmt3L is a transcriptional repressor that recruits histone deacetylase. 2002, Pubmed
Deshpande, Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. 2009, Pubmed
Detich, Promoter-specific activation and demethylation by MBD2/demethylase. 2002, Pubmed
Dhasarathy, The MBD protein family-reading an epigenetic mark? 2008, Pubmed
Dintilhac, HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. 2002, Pubmed
Eckhardt, DNA methylation profiling of human chromosomes 6, 20 and 22. 2006, Pubmed
Ego, Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR. 2005, Pubmed
Engel, Conserved DNA methylation in Gadd45a(-/-) mice. 2009, Pubmed
Fatemi, Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. 2002, Pubmed
Feng, The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. 2001, Pubmed
Field, DNA methylation in insects. 2004, Pubmed
Filion, A family of human zinc finger proteins that bind methylated DNA and repress transcription. 2006, Pubmed
Fraga, The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. 2003, Pubmed , Xenbase
Fujita, Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. 2000, Pubmed
Fujita, MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. 2004, Pubmed
Fujita, Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. 2003, Pubmed
Fuks, The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. 2003, Pubmed
Fuks, The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. 2003, Pubmed
Fukushige, RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression. 2006, Pubmed
Geerdink, MECP2 mutation in a boy with severe neonatal encephalopathy: clinical, neuropathological and molecular findings. 2002, Pubmed
Giacometti, Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2. 2007, Pubmed
Goll, Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. 2006, Pubmed
Gowher, De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases. 2005, Pubmed , Xenbase
Gu, Differential recruitment of methylated CpG binding domains by the orphan receptor GCNF initiates the repression and silencing of Oct4 expression. 2006, Pubmed
Guy, Reversal of neurological defects in a mouse model of Rett syndrome. 2007, Pubmed
Guy, A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. 2001, Pubmed
Harikrishnan, Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. 2005, Pubmed
Hata, Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. 2002, Pubmed
Hendrich, Identification and characterization of a family of mammalian methyl-CpG binding proteins. 1998, Pubmed
Hendrich, The methyl-CpG binding domain and the evolving role of DNA methylation in animals. 2003, Pubmed
Hendrich, Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. 2001, Pubmed
Hendrich, The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. 1999, Pubmed
Hermann, The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity. 2003, Pubmed
Horike, Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. 2005, Pubmed
Howell, Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. 2001, Pubmed
Hu, Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. 2006, Pubmed , Xenbase
Hung, Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases. 1999, Pubmed
Hutchins, Gene silencing quantitatively controls the function of a developmental trans-activator. 2002, Pubmed
Ichimura, Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. 2005, Pubmed
Iguchi-Ariga, CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. 1989, Pubmed
Iwano, Xenopus MBD3 plays a crucial role in an early stage of development. 2004, Pubmed , Xenbase
Jackson-Grusby, Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. 2001, Pubmed
Jeffery, Components of the DNA methylation system of chromatin control are RNA-binding proteins. 2004, Pubmed
Jeltsch, Molecular enzymology of mammalian DNA methyltransferases. 2006, Pubmed
Jin, GADD45A does not promote DNA demethylation. 2008, Pubmed
Johnston, Neurobiology of Rett syndrome: a genetic disorder of synapse development. 2001, Pubmed
Jones, Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. 1998, Pubmed , Xenbase
Jordan, Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets. 2007, Pubmed
Jørgensen, Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. 2004, Pubmed
Kaji, Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. 2007, Pubmed
Kaji, The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. 2006, Pubmed
Kiefer, Epigenetics in development. 2007, Pubmed
Kimura, Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. 2003, Pubmed
Klose, Genomic DNA methylation: the mark and its mediators. 2006, Pubmed
Klose, DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. 2005, Pubmed
Klose, MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. 2004, Pubmed , Xenbase
Kokura, The Ski protein family is required for MeCP2-mediated transcriptional repression. 2001, Pubmed
Kondo, The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes. 2005, Pubmed
Kucharski, Nutritional control of reproductive status in honeybees via DNA methylation. 2008, Pubmed
Kuczewski, Activity-dependent dendritic release of BDNF and biological consequences. 2009, Pubmed
Kunert, A Dnmt2-like protein mediates DNA methylation in Drosophila. 2003, Pubmed
Lalande, Molecular epigenetics of Angelman syndrome. 2007, Pubmed
Le Guezennec, MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. 2006, Pubmed
Li, Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. 1992, Pubmed
Liang, Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. 2002, Pubmed
Lopez-Serra, Proteins that bind methylated DNA and human cancer: reading the wrong words. 2008, Pubmed
Luikenhuis, Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. 2004, Pubmed
Lunyak, REST and peace for the neuronal-specific transcriptional program. 2004, Pubmed
Lunyak, Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. 2002, Pubmed
Lyko, DNA methylation in Drosophila melanogaster. 2000, Pubmed
Lyst, Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins. 2006, Pubmed
MacKay, Immunological detection of changes in genomic DNA methylation during early zebrafish development. 2007, Pubmed
Macleod, Absence of genome-wide changes in DNA methylation during development of the zebrafish. 1999, Pubmed
Mann, Epigenetic reprogramming in the mammalian embryo: struggle of the clones. 2002, Pubmed
Marhold, The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2. 2004, Pubmed
Marhold, The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA. 2004, Pubmed
Martens, The profile of repeat-associated histone lysine methylation states in the mouse epigenome. 2005, Pubmed
Martín Caballero, The methyl-CpG binding proteins Mecp2, Mbd2 and Kaiso are dispensable for mouse embryogenesis, but play a redundant function in neural differentiation. 2009, Pubmed
Martinowich, DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. 2003, Pubmed
Mayer, Demethylation of the zygotic paternal genome. 2000, Pubmed
McGowan, DNA methylation and genome imprinting in the zebrafish, Danio rerio: some evolutionary ramifications. 1997, Pubmed
Meehan, DNA methylation in animal development. 2003, Pubmed
Mello, The ins and outs of nucleosome assembly. 2001, Pubmed
Mikkelsen, Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. 2007, Pubmed
Millar, Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. 2002, Pubmed
Morgan, Epigenetic reprogramming in mammals. 2005, Pubmed
Nakashima, Expression analysis and mutation detection of DLX5 and DLX6 in autism. 2010, Pubmed
Nan, Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. 1993, Pubmed
Nan, Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. 2007, Pubmed
Nan, Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. 1998, Pubmed
Ng, MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. 1999, Pubmed
Oda, DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. 2006, Pubmed
Ohki, Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1. 1999, Pubmed
Okano, DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. 1999, Pubmed
Okano, Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. 1998, Pubmed
Oswald, Active demethylation of the paternal genome in the mouse zygote. 2000, Pubmed
Palacios, The epigenetic network regulating muscle development and regeneration. 2006, Pubmed
Patel, Determination of trace amounts of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography. 1987, Pubmed
Pradhan, CXXC domain of human DNMT1 is essential for enzymatic activity. 2008, Pubmed
Pradhan, Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. 1999, Pubmed
Proffitt, 5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA. 1984, Pubmed
Prokhortchouk, Kaiso-deficient mice show resistance to intestinal cancer. 2006, Pubmed , Xenbase
Prokhortchouk, The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. 2001, Pubmed
Rai, DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. 2008, Pubmed
Rai, Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. 2006, Pubmed
Rai, Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. 2007, Pubmed
Rainier, Relaxation of imprinted genes in human cancer. 1993, Pubmed
Reese, The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1. 2003, Pubmed
Reik, Epigenetic reprogramming in mammalian development. 2001, Pubmed
Riccio, The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. 1999, Pubmed
Rietveld, In vivo repression of an erythroid-specific gene by distinct corepressor complexes. 2002, Pubmed
Robertson, DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. 2000, Pubmed
Roder, Transcriptional repression by Drosophila methyl-CpG-binding proteins. 2000, Pubmed
Rupp, When the embryonic genome flexes its muscles. 2002, Pubmed
Ruzov, The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways. 2009, Pubmed , Xenbase
Ruzov, Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. 2004, Pubmed , Xenbase
Saito, The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. 2002, Pubmed
Sansom, Deficiency of Mbd2 suppresses intestinal tumorigenesis. 2003, Pubmed
Sarraf, Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. 2004, Pubmed
Schmitz, TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. 2009, Pubmed
Schmitzová, A family of major royal jelly proteins of the honeybee Apis mellifera L. 1998, Pubmed
Schüle, DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. 2007, Pubmed
Screaton, Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. 2003, Pubmed
Selker, The methylated component of the Neurospora crassa genome. 2003, Pubmed
Shahbazian, Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. 2002, Pubmed
Sharif, The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. 2007, Pubmed
Smart, BDNF induces translocation of initiation factor 4E to mRNA granules: evidence for a role of synaptic microfilaments and integrins. 2003, Pubmed
Stancheva, DNA methylation at promoter regions regulates the timing of gene activation in Xenopus laevis embryos. 2002, Pubmed , Xenbase
Stancheva, Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos. 2000, Pubmed , Xenbase
Stancheva, A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos. 2003, Pubmed , Xenbase
Stancheva, Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos. 2001, Pubmed , Xenbase
Tamaru, A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. 2001, Pubmed
Tao, Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. 2009, Pubmed
Tatematsu, MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. 2000, Pubmed
Traynor, Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations. 2002, Pubmed
Tropea, Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. 2009, Pubmed
Tudor, Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. 2002, Pubmed
Tweedie, Methylation of genomes and genes at the invertebrate-vertebrate boundary. 1997, Pubmed
Uno, Expression, purification and characterization of methyl DNA binding protein from Bombyx mori. 2005, Pubmed
Veenstra, Constitutive genomic methylation during embryonic development of Xenopus. 2001, Pubmed , Xenbase
Villa, The methyl-CpG binding protein MBD1 is required for PML-RARalpha function. 2006, Pubmed
Wade, Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. 1999, Pubmed , Xenbase
Wade, Methyl CpG-binding proteins and transcriptional repression. 2001, Pubmed
Wagner, The spatial targeting and nuclear matrix binding domains of SRm160. 2003, Pubmed
Wallace, We gather together: insulators and genome organization. 2007, Pubmed
Wang, Functional CpG methylation system in a social insect. 2006, Pubmed
Watanabe, Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. 2003, Pubmed
Weber, Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. 2005, Pubmed
Weitzel, Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG-binding protein MeCP2. 1997, Pubmed
Weksberg, Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development. 2003, Pubmed
Wilson, Restriction and modification systems. 1991, Pubmed
Wolffe, DNA demethylation. 1999, Pubmed
Wong, Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. 2002, Pubmed
Woo, VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization. 2007, Pubmed
Wood, Genomic imprinting in mammals: emerging themes and established theories. 2006, Pubmed
Xu, Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. 1999, Pubmed
Yasui, Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. 2007, Pubmed
Yoder, Cytosine methylation and the ecology of intragenomic parasites. 1997, Pubmed
Yoon, N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. 2003, Pubmed
Young, Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. 2005, Pubmed
Zeev, Rett syndrome: clinical manifestations in males with MECP2 mutations. 2002, Pubmed
Zeitlin, Pre-mRNA splicing and the nuclear matrix. 1987, Pubmed
Zhang, Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. 1999, Pubmed
Zhao, Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. 2003, Pubmed
Zhou, Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. 2006, Pubmed