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XB-ART-12
FEBS Lett 2006 Sep 04;58020:4947-52. doi: 10.1016/j.febslet.2006.08.012.
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Xenopus ElrB, but not ElrA, binds RNA as an oligomer: possible role of the linker.

Devaux A , Colegrove-Otero LJ , Standart N .


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We have shown that ElrA and ElrB, Xenopus ELAV homologues, bind the Vg1 mRNA 3'UTR translation element in Xenopus oocytes and implicated ElrB in mediating translational repression during oogenesis. Here we report that, while ElrA and ElrB are 69% identical and both exhibit RNA binding in the nM range, recombinant ElrB, but not ElrA, is able to oligomerise. This oligomerisation is also seen with the endogenous protein. Both RNA binding and oligomerisation require the linker region flanked with two RNA recognition motifs. Our data demonstrate a novel and unique property of ElrB which may be important for its function as a translational regulator.

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Species referenced: Xenopus laevis
Genes referenced: elavl1 elavl2 gdf1