Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Acute morphogenic and chemotropic effects of neurotrophins on cultured embryonic Xenopus spinal neurons.
Ming Gl
,
Lohof AM
,
Zheng JQ
.
???displayArticle.abstract???
Neurotrophins constitute a family of trophic factors with profound effects on the survival and differentiation of the nervous system. Addition of brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), but not nerve growth factor (NGF), increased the survival of embryonic Xenopus spinal neurons in culture, although all three neurotrophins enhanced neurite outgrowth. Here we report that neurotrophins also exert acute actions on the morphology and motility of 1-day-old cultured Xenopus spinal neurons. Bath application of BDNF induced extensive formation of lamellipodia simultaneously at multiple sites along the neurite shaft as well as at the growth cone. The BDNF-induced lamellipodia appeared within minutes, rapidly protruded to their greatest extent in about 10 min, and gradually disappeared thereafter, leaving behind newly formed thin lateral processes. When applied as microscopic concentration gradients, both BDNF and NT-3, but not NGF, induced the growth cone to grow toward the neurotrophin source. Our results suggest that neurotrophic factors, when delivered to responsive neurons, may serve as morphogenic and chemotropic agents during neuronal development.
Aletta,
Growth cone configuration and advance: a time-lapse study using video-enhanced differential interference contrast microscopy.
1988, Pubmed
Aletta,
Growth cone configuration and advance: a time-lapse study using video-enhanced differential interference contrast microscopy.
1988,
Pubmed
Bailey,
Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7.
1988,
Pubmed
Bailey,
Structural changes accompanying memory storage.
1993,
Pubmed
Barbacid,
The Trk family of neurotrophin receptors.
1994,
Pubmed
Barbacid,
Neurotrophic factors and their receptors.
1995,
Pubmed
Barde,
Trophic factors and neuronal survival.
1989,
Pubmed
Barde,
The nerve growth factor family.
1990,
Pubmed
Barker,
Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.
1995,
Pubmed
Berninger,
Fast actions of neurotrophic factors.
1996,
Pubmed
Boulton,
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
1991,
Pubmed
Bray,
Cortical flow in animal cells.
1988,
Pubmed
Chao,
Neurotrophin receptors: a window into neuronal differentiation.
1992,
Pubmed
Cohen-Cory,
Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo.
1995,
Pubmed
,
Xenbase
Connolly,
Rapid regulation of neuronal growth cone shape and surface morphology by nerve growth factor.
1987,
Pubmed
Connolly,
Regulation of growth cone morphology by nerve growth factor: a comparative study by scanning electron microscopy.
1985,
Pubmed
Davies,
The role of neurotrophins in the developing nervous system.
1994,
Pubmed
Davies,
Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor.
,
Pubmed
Dechant,
Neurotrophin receptors.
1994,
Pubmed
Desmond,
Changes in the postsynaptic density with long-term potentiation in the dentate gyrus.
1986,
Pubmed
Ernfors,
Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis.
1991,
Pubmed
Funakoshi,
Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.
1993,
Pubmed
Glanzman,
Target-dependent structural changes accompanying long-term synaptic facilitation in Aplysia neurons.
1990,
Pubmed
Greene,
Early events in neurotrophin signalling via Trk and p75 receptors.
1995,
Pubmed
Griffin,
Rapid retraction of neurites by sensory neurons in response to increased concentrations of nerve growth factor.
1980,
Pubmed
Gundersen,
Characterization of the turning response of dorsal root neurites toward nerve growth factor.
1980,
Pubmed
Halegoua,
Changes in the phosphorylation and distribution of vinculin during nerve growth factor induced neurite outgrowth.
1987,
Pubmed
Hallböök,
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.
1991,
Pubmed
,
Xenbase
Hallböök,
Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo.
1993,
Pubmed
Henderson,
Neurotrophins promote motor neuron survival and are present in embryonic limb bud.
1993,
Pubmed
Heumann,
Neurotrophin signalling.
1994,
Pubmed
Hyman,
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.
1991,
Pubmed
Ip,
Neurotrophic factors and their receptors.
1995,
Pubmed
Isackson,
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF.
1991,
Pubmed
Kaplan,
Neurotrophin signal transduction by the Trk receptor.
1994,
Pubmed
Kater,
Regulation of growth cone behavior by calcium.
1991,
Pubmed
Kennedy,
Guidance and induction of branch formation in developing axons by target-derived diffusible factors.
1995,
Pubmed
Klein,
Role of neurotrophins in mouse neuronal development.
1994,
Pubmed
Knüsel,
K-252 compounds: modulators of neurotrophin signal transduction.
1992,
Pubmed
Kotani,
Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling.
1995,
Pubmed
Kuffler,
Promoting and directing axon outgrowth.
1994,
Pubmed
Letourneau,
Chemotactic response of nerve fiber elongation to nerve growth factor.
1978,
Pubmed
Lewin,
Physiology of the neurotrophins.
1996,
Pubmed
Lo,
Neurotrophic factors and synaptic plasticity.
1995,
Pubmed
Lohof,
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.
1993,
Pubmed
,
Xenbase
Lohof,
Asymmetric modulation of cytosolic cAMP activity induces growth cone turning.
1992,
Pubmed
,
Xenbase
Lu,
Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons.
1991,
Pubmed
Lumsden,
Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor.
,
Pubmed
Lundborg,
Trophism, tropism, and specificity in nerve regeneration.
1994,
Pubmed
Maisonpierre,
NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
1990,
Pubmed
Mason,
Growth cone form is behavior-specific and, consequently, position-specific along the retinal axon pathway.
1997,
Pubmed
McAllister,
Neurotrophin regulation of cortical dendritic growth requires activity.
1996,
Pubmed
McAllister,
Neurotrophins regulate dendritic growth in developing visual cortex.
1995,
Pubmed
McTigue,
Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities.
1985,
Pubmed
Menesini Chen,
Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodent upon intracerebral NGF injections.
1978,
Pubmed
Obermeier,
Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.
1993,
Pubmed
Obermeier,
Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.
1994,
Pubmed
Ohmichi,
Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains.
1992,
Pubmed
Parker,
Intracellular signalling. PI 3-kinase puts GTP on the Rac.
1995,
Pubmed
Patterson,
Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs.
1992,
Pubmed
Ruit,
Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development.
1992,
Pubmed
Sato,
Action of a diffusible target-derived chemoattractant on cortical axon branch induction and directed growth.
1994,
Pubmed
Schnell,
Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion.
1994,
Pubmed
Seeley,
Short-latency local actions of nerve growth factor at the growth cone.
1983,
Pubmed
Segal,
Intracellular signaling pathways activated by neurotrophic factors.
1996,
Pubmed
Segal,
Changes in neurotrophin responsiveness during the development of cerebellar granule neurons.
1992,
Pubmed
Small,
Organization of actin meshworks in cultured cells: the leading edge.
1982,
Pubmed
Smith,
Neuronal cytomechanics: the actin-based motility of growth cones.
1988,
Pubmed
Snider,
Neurotrophic molecules.
1989,
Pubmed
Snider,
Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.
1994,
Pubmed
Song,
cAMP-induced switching in turning direction of nerve growth cones.
1997,
Pubmed
,
Xenbase
Spitzer,
The development of the action potential mechanism of amphibian neurons isolated in culture.
1976,
Pubmed
,
Xenbase
Stoop,
Synaptic modulation by neurotrophic factors: differential and synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor.
1996,
Pubmed
,
Xenbase
Tanaka,
Making the connection: cytoskeletal rearrangements during growth cone guidance.
1995,
Pubmed
Tapley,
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.
1992,
Pubmed
Tessier-Lavigne,
The molecular biology of axon guidance.
1996,
Pubmed
Thoenen,
Neurotrophins and neuronal plasticity.
1995,
Pubmed
Vetter,
Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.
1991,
Pubmed
Wennström,
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling.
1994,
Pubmed
Zhang,
NGF and NT-3 have differing effects on the growth of dorsal root axons in developing mammalian spinal cord.
1994,
Pubmed
Zheng,
Turning of nerve growth cones induced by neurotransmitters.
1994,
Pubmed
,
Xenbase
Zheng,
Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient.
1996,
Pubmed
,
Xenbase
