Eur J Immunol 1999 May 01;295:1729-39. doi: 10.1002/(SICI)1521-4141(199905)29:05<1729::AID-IMMU1729>3.0.CO;2-K.

Duplication and MHC linkage of the CTX family of genes in Xenopus and in mammals.

???displayArticle.abstract???
The effects of whole genome duplications that characterize the evolution of vertebrates have been studied on the gene of the Xenopus thymocyte molecule CTX and its mammalian relatives. CTX, with an extracellular part consisting of one V and one C2 external domain, defines a new subset of the immunoglobulin superfamily and is conserved from amphibians to mammals. The number of CTX loci, their polymorphism, and their genetic linkages have been studied in several Xenopus species and in humans. In the genetically simplest species, X. tropicalis (2n = 20), the unique CTX locus is linked to the MHC. In the polyploid species, all CTX genes, unlike many other immune system genes, have remained in the genome; i.e. there are two CTX loci in the tetraploid species X. laevis (2n = 6) and six CTX loci in the dodecaploid species X. ruwenzoriensis (2n = 108). In X. laevis, one CTX gene is linked to the MHC and the other not, presumably because one set of MHC class I and II has been deleted from the corresponding linkage group. The various mammalian homologues are less related to each other than are the Xenopus CTX genes among each other, and they do not cross-hybridize with each other because they stem from the ancient polyploidization. Some human CTX homologies are on chromosomes 11 and 21, but others are on chromosomes 1, 6 and 19, which contain MHC paralogous regions; this suggests that a very ancient linkage group has been preserved.

???displayArticle.pubmedLink??? 10359128
???displayArticle.link??? Eur J Immunol


Species referenced: Xenopus laevis
Genes referenced: mhc1a myh4 myh6 vsig1