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XB-ART-24151
Ciba Found Symp 1992 Jan 01;165:219-30; discussion 230-4. doi: 10.1002/9780470514221.ch13.
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The TGF-beta-related DVR gene family in mammalian development.

Lyons KM , Jones CM , Hogan BL .


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The genes that encode the bone morphogenetic proteins and the Vg-related proteins are mammalian members of a group of TGF-beta-related genes, designated the DVR family, that includes the decapentaplegic gene of Drosophila and the Vg1 gene of Xenopus. Members of the DVR (decapentaplegic-Vg-related) family have been implicated in diverse processes during development, particularly in epithelial-mesenchymal interactions. The results of our in situ hybridization studies with postimplantation mouse embryos provide evidence for the involvement of DVR family members, particularly DVR-2, DVR-4 and DVR-6, in specific inductive interactions during the development of many organs, including the limb, the whisker follicle and the heart.

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Species referenced: Xenopus
Genes referenced: bmp4 gdf1 tgfb1