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XB-ART-15670
Nature 1997 Oct 23;3896653:816-24. doi: 10.1038/39807.
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The capsaicin receptor: a heat-activated ion channel in the pain pathway.

Caterina MJ , Schumacher MA , Tominaga M , Rosen TA , Levine JD , Julius D .


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Capsaicin, the main pungent ingredient in 'hot' chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. We have used an expression cloning strategy based on calcium influx to isolate a functional cDNA encoding a capsaicin receptor from sensory neurons. This receptor is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.

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References :
Clapham, Some like it hot: spicing up ion channels. 1997, Pubmed