XB-ART-35140
Invert Neurosci
2007 Mar 01;71:17-30. doi: 10.1007/s10158-006-0036-9.
Show Gene links
Show Anatomy links
Insect sodium channels and insecticide resistance.
Dong K
.
???displayArticle.abstract???
Voltage-gated sodium channels are essential for the generation and propagation of action potentials (i.e., electrical impulses) in excitable cells. Although most of our knowledge about sodium channels is derived from decades of studies of mammalian isoforms, research on insect sodium channels is revealing both common and unique aspects of sodium channel biology. In particular, our understanding of the molecular dynamics and pharmacology of insect sodium channels has advanced greatly in recent years, thanks to successful functional expression of insect sodium channels in Xenopus oocytes and intensive efforts to elucidate the molecular basis of insect resistance to insecticides that target sodium channels. In this review, I discuss recent literature on insect sodium channels with emphases on the prominent role of alternative splicing and RNA editing in the generation of functionally diverse sodium channels in insects and the current understanding of the interactions between insect sodium channels and insecticides.
???displayArticle.pubmedLink??? 17206406
???displayArticle.pmcLink??? PMC3052376
???displayArticle.link??? Invert Neurosci
???displayArticle.grants??? [+]
References [+] :
Bass,
Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of the cat flea, Ctenocephalides felis.
2004, Pubmed
Bass, Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of the cat flea, Ctenocephalides felis. 2004, Pubmed
Bosmans, The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel. 2005, Pubmed , Xenbase
Brun-Barale, Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and development of a diagnostic test. 2005, Pubmed
Byerly, Ionic currents of Drosophila neurons in embryonic cultures. 1988, Pubmed
Catterall, From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. 2000, Pubmed
Catterall, International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels. 2003, Pubmed
Cestèle, Molecular mechanisms of neurotoxin action on voltage-gated sodium channels. 2000, Pubmed
Choi, Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes. 2006, Pubmed , Xenbase
Crill, Persistent sodium current in mammalian central neurons. 1996, Pubmed
Defaix, Role of a novel maintained low-voltage-activated inward current permeable to sodium and calcium in pacemaking of insect neurosecretory neurons. 2005, Pubmed
Derst, Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. 2006, Pubmed , Xenbase
Dib-Hajj, NaN/Nav1.9: a sodium channel with unique properties. 2002, Pubmed
Dong, A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. 1997, Pubmed
Du, An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 2006, Pubmed
Feng, Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function. 1995, Pubmed , Xenbase
Forcioli, High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the western flower thrips (Thysanoptera: Thripidae). 2002, Pubmed
Ginsburg, Differential sensitivity of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels to the insecticide allethrin in rat dorsal root ganglion neurons. 1993, Pubmed
Goldin, Nomenclature of voltage-gated sodium channels. 2000, Pubmed
Goldin, Resurgence of sodium channel research. 2001, Pubmed
Goldin, Diversity of mammalian voltage-gated sodium channels. 1999, Pubmed
Goldin, Mechanisms of sodium channel inactivation. 2003, Pubmed
Grolleau, Dorsal unpaired median neurones in the insect central nervous system: towards a better understanding of the ionic mechanisms underlying spontaneous electrical activity. 2000, Pubmed
Guerrero, Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans: identification of kdr and super-kdr point mutations. 1997, Pubmed
Hanrahan, RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation. 2000, Pubmed
He, Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant cattle tick. 1999, Pubmed
Hille, Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. 1977, Pubmed
Ingles, Characterization of voltage-sensitive sodium channel gene coding sequences from insecticide-susceptible and knockdown-resistant house fly strains. 1996, Pubmed
Kulkarni, The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster. 2002, Pubmed
Lapied, Biophysical properties of scorpion alpha-toxin-sensitive background sodium channel contributing to the pacemaker activity in insect neurosecretory cells (DUM neurons). 1999, Pubmed
Lapied, Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels. 2001, Pubmed
Le Corronc, Ionic mechanisms underlying depolarizing responses of an identified insect motor neuron to short periods of hypoxia. 1999, Pubmed
Lee, Mutations in the house fly Vssc1 sodium channel gene associated with super-kdr resistance abolish the pyrethroid sensitivity of Vssc1/tipE sodium channels expressed in Xenopus oocytes. 1999, Pubmed , Xenbase
Lee, Developmental regulation of alternative exon usage in the house fly Vssc1 sodium channel gene. 2002, Pubmed
Lee, The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethroid sensitivity of house fly sodium channels expressed in Xenopus oocytes. 2001, Pubmed , Xenbase
Littleton, Ion channels and synaptic organization: analysis of the Drosophila genome. 2000, Pubmed
Liu, Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides. 2000, Pubmed
Liu, Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide. 2002, Pubmed
Liu, Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. 2004, Pubmed
Liu, Alternative splicing of the BSC1 gene generates tissue-specific isoforms in the German cockroach. 2001, Pubmed
Liu, Effect of a fluvalinate-resistance-associated sodium channel mutation from varroa mites on cockroach sodium channel sensitivity to fluvalinate, a pyrethroid insecticide. 2006, Pubmed , Xenbase
Loughney, Molecular analysis of the para locus, a sodium channel gene in Drosophila. 1989, Pubmed
Martinez-Torres, A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in the peach-potato aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae). 1999, Pubmed
Martinez-Torres, Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anopheles gambiae s.s. 1998, Pubmed
McCann, The discovery of indoxacarb: oxadiazines as a new class of pyrazoline-type insecticides. 2001, Pubmed
Miyazaki, Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant German cockroaches (Blattella germanica) and house fly (Musca domestica). 1996, Pubmed
Narahashi, Neuroreceptors and ion channels as the basis for drug action: past, present, and future. 2000, Pubmed
Narahashi, Neuronal ion channels as the target sites of insecticides. 1996, Pubmed
Narahashi, Toxins that modulate the sodium channel gating mechanism. 1986, Pubmed
Numann, Functional modulation of brain sodium channels by protein kinase C phosphorylation. 1991, Pubmed
O'Dowd, Sodium current density correlates with expression of specific alternatively spliced sodium channel mRNAs in single neurons. 1995, Pubmed
O'Reilly, Modelling insecticide-binding sites in the voltage-gated sodium channel. 2006, Pubmed
Palladino, A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. 2000, Pubmed
Park, A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with pyrethroid resistance in Heliothis virescens F. 1997, Pubmed
Park, A novel mutation L1029H in sodium channel gene hscp associated with pyrethroid resistance for Heliothis virescens (Lepidoptera:Noctuidae). 1997, Pubmed
Plummer, Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells. 1997, Pubmed
Ranson, Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids. 2000, Pubmed
Raymond-Delpech, Ion channels: molecular targets of neuroactive insecticides. 2005, Pubmed
Reenan, The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing. 2000, Pubmed
Saito, Ionic channels in cultured Drosophila neurons. 1993, Pubmed
Saito, Expression of ion channels and mutational effects in giant Drosophila neurons differentiated from cell division-arrested embryonic neuroblasts. 1991, Pubmed
Salgado, Slow voltage-dependent block of sodium channels in crayfish nerve by dihydropyrazole insecticides. 1992, Pubmed
Salkoff, Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila. 1987, Pubmed
Schäfer, Ionic currents of Kenyon cells from the mushroom body of the honeybee. 1994, Pubmed
Seeburg, RNA helicase participates in the editing game. 2000, Pubmed
Silver, State-dependent block of rat Nav1.4 sodium channels expressed in xenopus oocytes by pyrazoline-type insecticides. 2005, Pubmed , Xenbase
Silver, Differential sensitivity of rat voltage-sensitive sodium channel isoforms to pyrazoline-type insecticides. 2006, Pubmed , Xenbase
Smith, Potentiation of rat brain sodium channel currents by PKA in Xenopus oocytes involves the I-II linker. 2000, Pubmed , Xenbase
Smith, Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A. 1997, Pubmed , Xenbase
Smith, The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyrethroids. 1997, Pubmed , Xenbase
Smith, Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes. 1996, Pubmed , Xenbase
Smith, Action of the pyrethroid insecticide cypermethrin on rat brain IIa sodium channels expressed in xenopus oocytes. 1998, Pubmed , Xenbase
Soderlund, The molecular biology of knockdown resistance to pyrethroid insecticides. 2003, Pubmed
Soderlund, Neurotoxic actions of pyrethroid insecticides. 1989, Pubmed
Song, Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin. 1996, Pubmed
Song, RNA editing generates tissue-specific sodium channels with distinct gating properties. 2004, Pubmed , Xenbase
Song, Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. 2006, Pubmed , Xenbase
Strugatsky, Genetic polymorphism and expression of a highly potent scorpion depressant toxin enable refinement of the effects on insect Na channels and illuminate the key role of Asn-58. 2005, Pubmed
Tan, Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. 2002, Pubmed , Xenbase
Tan, Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. 2005, Pubmed , Xenbase
Tan, Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 2002, Pubmed , Xenbase
Tatebayashi, Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. 1994, Pubmed
Thackeray, Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. 1994, Pubmed
Thackeray, Conserved alternative splicing patterns and splicing signals in the Drosophila sodium channel gene para. 1995, Pubmed
Tomita, Molecular analysis of a para sodium channel gene from pyrethroid-resistant head lice, Pediculus humanus capitis (Anoplura: Pediculidae). 2003, Pubmed
Trainer, High affinity binding of pyrethroids to the alpha subunit of brain sodium channels. 1997, Pubmed
Tsurubuchi, Modulation of sodium channels by the oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite in rat dorsal root ganglion neurons. 2003, Pubmed
Vais, Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids. 2003, Pubmed , Xenbase
Vais, Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations. 2000, Pubmed , Xenbase
Vais, A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides. 2000, Pubmed , Xenbase
Vais, The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. 2001, Pubmed , Xenbase
Vais, Functional analysis of a rat sodium channel carrying a mutation for insect knock-down resistance (kdr) to pyrethroids. 1997, Pubmed , Xenbase
Wang, Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. 2003, Pubmed
Wang, A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action. 2001, Pubmed
Wang, Molecular characterization of an arachnid sodium channel gene from the varroa mite (Varroa destructor). 2003, Pubmed
Warmke, Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. 1997, Pubmed , Xenbase
West, A phosphorylation site in the Na+ channel required for modulation by protein kinase C. 1991, Pubmed
Wicher, Non-synaptic ion channels in insects--basic properties of currents and their modulation in neurons and skeletal muscles. 2001, Pubmed
Williamson, Identification of mutations in the housefly para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides. 1996, Pubmed
Xu, Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance. 2005, Pubmed
Yu, Overview of the voltage-gated sodium channel family. 2003, Pubmed
Zhao, Voltage-dependent block of sodium channels in mammalian neurons by the oxadiazine insecticide indoxacarb and its metabolite DCJW. 2003, Pubmed
Zhao, Block of two subtypes of sodium channels in cockroach neurons by indoxacarb insecticides. 2005, Pubmed
Zhao, Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel. 2000, Pubmed , Xenbase
Zhou, A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. 2004, Pubmed , Xenbase
Zlotkin, The insect voltage-gated sodium channel as target of insecticides. 1999, Pubmed