Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
A voltage-gated calcium-selective channel encoded by a sodium channel-like gene.
Zhou W
,
Chung I
,
Liu Z
,
Goldin AL
,
Dong K
.
???displayArticle.abstract???
BSC1, which was originally identified by its sequence similarity to voltage-gated Na(+) channels, encodes a functional voltage-gated cation channel whose properties differ significantly from Na(+) channels. BSC1 has slower kinetics of activation and inactivation than Na(+) channels, it is more selective for Ba(2+) than for Na(+), it is blocked by Cd(2+), and Na(+) currents through BSC1 are blocked by low concentrations of Ca(2+). All of these properties are more similar to voltage-gated Ca(2+) channels than to voltage-gated Na(+) channels. The selectivity for Ba(2+) is partially due to the presence of a glutamate in the pore-forming region of domain III, since replacing that residue with lysine (normally present in voltage-gated Na(+) channels) makes the channel more selective for Na(+). BSC1 appears to be the prototype of a novel family of invertebrate voltage-dependent cation channels with a close structural and evolutionary relationship to voltage-gated Na(+) and Ca(2+) channels.
Almers,
A non-selective cation conductance in frog muscle membrane blocked by micromolar external calcium ions.
1984, Pubmed
Almers,
A non-selective cation conductance in frog muscle membrane blocked by micromolar external calcium ions.
1984,
Pubmed
Almers,
Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore.
1984,
Pubmed
Amat,
Na+-Dependent neuritic spikes initiate Ca2+-dependent somatic plateau action potentials in insect dorsal paired median neurons.
1998,
Pubmed
Anderson,
Phylogeny of ion channels: clues to structure and function.
2001,
Pubmed
Castella,
DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster.
2001,
Pubmed
Catterall,
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
2000,
Pubmed
Chiamvimonvat,
Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.
1996,
Pubmed
,
Xenbase
Dong,
A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach.
1997,
Pubmed
Eberl,
Genetic and developmental characterization of Dmca1D, a calcium channel alpha1 subunit gene in Drosophila melanogaster.
1998,
Pubmed
Favre,
On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel.
1996,
Pubmed
,
Xenbase
Feng,
Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function.
1995,
Pubmed
,
Xenbase
Goldin,
Expression of ion channels by injection of mRNA into Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Goldin,
Evolution of voltage-gated Na(+) channels.
2002,
Pubmed
Grabner,
Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle.
1994,
Pubmed
Heinemann,
Calcium channel characteristics conferred on the sodium channel by single mutations.
1992,
Pubmed
,
Xenbase
Hille,
The Sharpey-Schafer Lecture. Ionic channels: evolutionary origins and modern roles.
1989,
Pubmed
Hiyama,
Na(x) channel involved in CNS sodium-level sensing.
2002,
Pubmed
Hong,
Spatial and temporal expression patterns of two sodium channel genes in Drosophila.
1994,
Pubmed
Jan,
Tracing the roots of ion channels.
1992,
Pubmed
Jan,
L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction.
1976,
Pubmed
Jeziorski,
Cloning and functional expression of a voltage-gated calcium channel alpha1 subunit from jellyfish.
1998,
Pubmed
,
Xenbase
Kimura,
Molecular cloning and characterization of a putative neural calcium channel alpha1-subunit from squid optic lobe.
1997,
Pubmed
Kulkarni,
The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster.
2002,
Pubmed
Kuruma,
Dynamics of calcium regulation of chloride currents in Xenopus oocytes.
1999,
Pubmed
,
Xenbase
Liu,
Alternative splicing of the BSC1 gene generates tissue-specific isoforms in the German cockroach.
2001,
Pubmed
Loughney,
Molecular analysis of the para locus, a sodium channel gene in Drosophila.
1989,
Pubmed
Nagahora,
Diversity of voltage-gated sodium channels in the ascidian larval nervous system.
2000,
Pubmed
Patton,
Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker.
1992,
Pubmed
Ren,
A prokaryotic voltage-gated sodium channel.
2001,
Pubmed
Salkoff,
Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila.
1987,
Pubmed
Smith,
A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects.
1996,
Pubmed
Smith,
The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyrethroids.
1997,
Pubmed
,
Xenbase
Spafford,
Genomic organization of a voltage-gated Na+ channel in a hydrozoan jellyfish: insights into the evolution of voltage-gated Na+ channel genes.
1999,
Pubmed
Strong,
Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability.
1993,
Pubmed
Tan,
Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin.
2002,
Pubmed
,
Xenbase
Tan,
Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels.
2002,
Pubmed
,
Xenbase
Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed
Tsien,
Intracellular measurements of ion activities.
1983,
Pubmed
Warmke,
Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology.
1997,
Pubmed
,
Xenbase
Watanabe,
A comparison of voluntary salt-intake behavior in Nax-gene deficient and wild-type mice with reference to peripheral taste inputs.
2003,
Pubmed
West,
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.
1992,
Pubmed
,
Xenbase
White,
Structure of a putative sodium channel from the sea anemone Aiptasia pallida.
1998,
Pubmed
Yang,
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels.
1993,
Pubmed
,
Xenbase
Yue,
The cation selectivity filter of the bacterial sodium channel, NaChBac.
2002,
Pubmed
