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XB-ART-2403
Cell 2005 Jan 28;1202:156-8. doi: 10.1016/j.cell.2005.01.006.
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Antagonizing Wnt and FGF receptors: an enemy from within (the ER).

He X .


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In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting anterior patterning in Xenopus.

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Species referenced: Xenopus
Genes referenced: shisa1 tbx2

References :
Yamamoto, Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. 2005, Pubmed, Xenbase