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Proc Natl Acad Sci U S A
2006 Oct 31;10344:16460-5. doi: 10.1073/pnas.0607776103.
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Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.
Glaser S
,
Metcalf D
,
Wu L
,
Hart AH
,
DiRago L
,
Mifsud S
,
D'Amico A
,
Dagger S
,
Campo C
,
Chan AC
,
Izon DJ
,
Robb L
.
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Mixl1, the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendodermal structures during early embryogenesis. Gene targeting and overexpression studies have implicated Mixl1 as a regulator of hematopoiesis arising in differentiating embryonic stem cells. To assess the role of Mixl1 in the regulation of adult hematopoiesis, we overexpressed Mixl1 in murine bone marrow using a retroviral transduction/transplantation model. Enforced expression of Mixl1 profoundly perturbed hematopoietic lineage commitment and differentiation, giving rise to abnormal myeloid progenitors and impairing erythroid and lymphoid differentiation. Moreover, all mice reconstituted with Mixl1-transduced bone marrow developed fatal, transplantable acute myeloid leukemia with a mean latency period of 200 days. These observations establish a link between enforced Mixl1 expression and leukemogenesis in the mouse.
Akashi,
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.
2000, Pubmed
Akashi,
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.
2000,
Pubmed
Casey,
Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development.
1999,
Pubmed
,
Xenbase
D'Amico,
The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3.
2003,
Pubmed
Debernardi,
Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events.
2003,
Pubmed
Ecochard,
A novel Xenopus mix-like gene milk involved in the control of the endomesodermal fates.
1998,
Pubmed
,
Xenbase
Fischbach,
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
2005,
Pubmed
Golub,
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.
1999,
Pubmed
Guo,
A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1.
2002,
Pubmed
,
Xenbase
Hart,
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo.
2002,
Pubmed
Hart,
Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.
2005,
Pubmed
Henry,
Mixer, a homeobox gene required for endoderm development.
1998,
Pubmed
,
Xenbase
Keller,
In vitro differentiation of embryonic stem cells.
1995,
Pubmed
Kikuchi,
The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors.
2000,
Pubmed
,
Xenbase
Kogan,
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
2002,
Pubmed
Kroon,
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.
1998,
Pubmed
Latinkic,
Goosecoid and mix.1 repress Brachyury expression and are required for head formation in Xenopus.
1999,
Pubmed
,
Xenbase
Lawrence,
HOX genes: not just myeloid oncogenes any more.
2005,
Pubmed
Lemaire,
A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone.
1998,
Pubmed
,
Xenbase
Mead,
BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix.1.
1996,
Pubmed
,
Xenbase
Mohn,
Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos.
2003,
Pubmed
,
Xenbase
Ng,
The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells.
2005,
Pubmed
Owens,
HOX and non-HOX homeobox genes in leukemic hematopoiesis.
2002,
Pubmed
Pear,
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.
1998,
Pubmed
Pearce,
Mml, a mouse Mix-like gene expressed in the primitive streak.
1999,
Pubmed
,
Xenbase
Perkins,
Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.
1990,
Pubmed
Persons,
Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.
1999,
Pubmed
Poulain,
Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish.
2002,
Pubmed
,
Xenbase
Rawat,
Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.
2004,
Pubmed
Robb,
Cloning, expression analysis, and chromosomal localization of murine and human homologues of a Xenopus mix gene.
2000,
Pubmed
,
Xenbase
Rosa,
Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos.
1989,
Pubmed
,
Xenbase
Sauvageau,
Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.
1997,
Pubmed
,
Xenbase
Tada,
Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm.
1998,
Pubmed
,
Xenbase
Tarrant,
The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
2002,
Pubmed
Thorsteinsdottir,
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.
1997,
Pubmed
van den Akker,
Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation.
2002,
Pubmed
Willey,
Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.
2006,
Pubmed
Xanthos,
Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis.
2001,
Pubmed
,
Xenbase