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Biophys J
1996 Feb 01;702:754-61. doi: 10.1016/S0006-3495(96)79615-7.
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Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K(+)-selective permeation.
Reuveny E
,
Jan YN
,
Jan LY
.
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Inwardly rectifying K+ channels are highly selective for K+ ions and show strong interaction with ions in the pore. Both features are important for the physiological functions of these channels and pose intriguing mechanistic questions of ion permeation. The aspartate residue in the second putative transmembrane segment of the IRK1 inwardly rectifying K+ channel, previously implicated in inward rectification gating due to cytoplasmic Mg2+ and polyamine block, is found in this study to be crucial for the channel's ability to distinguish between K+ and Rb+ ions. Mutation of this residue also perturbs the interaction between the channel pore and the Sr2+ blocking ion. Our studies suggest that this aspartate residue contributes to a selectivity filter near the cytoplasmic end of the pore.
Aiyar,
The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway.
1994, Pubmed,
Xenbase
Aiyar,
The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway.
1994,
Pubmed
,
Xenbase
Biermans,
The mechanism of the inactivation of the inward-rectifying K current during hyperpolarizing steps in guinea-pig ventricular myocytes.
1987,
Pubmed
Choi,
The internal quaternary ammonium receptor site of Shaker potassium channels.
1993,
Pubmed
,
Xenbase
Collins,
The giant cardiac membrane patch method: stimulation of outward Na(+)-Ca2+ exchange current by MgATP.
1992,
Pubmed
De Biasi,
Histidine substitution identifies a surface position and confers Cs+ selectivity on a K+ pore.
1993,
Pubmed
Fakler,
Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine.
1995,
Pubmed
,
Xenbase
Ficker,
Spermine and spermidine as gating molecules for inward rectifier K+ channels.
1994,
Pubmed
,
Xenbase
Gay,
Cs(+) causes a voltage-dependent block of inward K currents in resting skeletal muscle fibres.
1977,
Pubmed
Goldman,
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES.
1943,
Pubmed
Hagiwara,
The anomalous rectification and cation selectivity of the membrane of a starfish egg cell.
1974,
Pubmed
Hartmann,
Exchange of conduction pathways between two related K+ channels.
1991,
Pubmed
,
Xenbase
Harvey,
Voltage-dependent block of cardiac inward-rectifying potassium current by monovalent cations.
1989,
Pubmed
Heginbotham,
Mutations in the K+ channel signature sequence.
1994,
Pubmed
,
Xenbase
Heginbotham,
Conduction properties of the cloned Shaker K+ channel.
1993,
Pubmed
,
Xenbase
Heginbotham,
A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels.
1992,
Pubmed
,
Xenbase
Hidalgo,
Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.
1995,
Pubmed
,
Xenbase
Hille,
Potassium channels as multi-ion single-file pores.
1978,
Pubmed
Ho,
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.
1993,
Pubmed
,
Xenbase
HODGKIN,
The effect of sodium ions on the electrical activity of giant axon of the squid.
1949,
Pubmed
HODGKIN,
The influence of potassium and chloride ions on the membrane potential of single muscle fibres.
1959,
Pubmed
Kavanaugh,
Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.
1991,
Pubmed
,
Xenbase
Kavanaugh,
Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium.
1992,
Pubmed
,
Xenbase
Kirsch,
Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores.
1993,
Pubmed
Kirsch,
A single nonpolar residue in the deep pore of related K+ channels acts as a K+:Rb+ conductance switch.
1992,
Pubmed
Kubo,
Primary structure and functional expression of a mouse inward rectifier potassium channel.
1993,
Pubmed
,
Xenbase
Kubo,
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
1993,
Pubmed
,
Xenbase
Liman,
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.
1992,
Pubmed
,
Xenbase
Lopatin,
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification.
1994,
Pubmed
,
Xenbase
Lopez,
Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore.
1994,
Pubmed
,
Xenbase
Lu,
A conductance maximum observed in an inward-rectifier potassium channel.
1994,
Pubmed
,
Xenbase
Lu,
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel.
1994,
Pubmed
,
Xenbase
Lü,
Silver as a probe of pore-forming residues in a potassium channel.
1995,
Pubmed
,
Xenbase
MacKinnon,
Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor.
1989,
Pubmed
,
Xenbase
MacKinnon,
Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels.
1990,
Pubmed
Matsuda,
Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+.
,
Pubmed
Mitra,
Permeance of Cs+ and Rb+ through the inwardly rectifying K+ channel in guinea pig ventricular myocytes.
1991,
Pubmed
Ohmori,
Inactivation kinetics and steady-state current noise in the anomalous rectifier of tunicate egg cell membranes.
1978,
Pubmed
Pascual,
K+ pore structure revealed by reporter cysteines at inner and outer surfaces.
1995,
Pubmed
,
Xenbase
Pérez-Cornejo,
The multi-ion nature of the pore in Shaker K+ channels.
1994,
Pubmed
Shieh,
Mutational analysis of ion conduction and drug binding sites in the inner mouth of voltage-gated K+ channels.
1994,
Pubmed
Shioya,
Fast and slow blockades of the inward-rectifier K+ channel by external divalent cations in guinea-pig cardiac myocytes.
1993,
Pubmed
Silver,
Effects of external Rb+ on inward rectifier K+ channels of bovine pulmonary artery endothelial cells.
1994,
Pubmed
Slesinger,
The S4-S5 loop contributes to the ion-selective pore of potassium channels.
1993,
Pubmed
,
Xenbase
Standen,
A potential- and time-dependent blockade of inward rectification in frog skeletal muscle fibres by barium and strontium ions.
1978,
Pubmed
Standen,
Rubidium block and rubidium permeability of the inward rectifier of frog skeletal muscle fibres.
1980,
Pubmed
Taglialatela,
Comparison of H5, S6, and H5-S6 exchanges on pore properties of voltage-dependent K+ channels.
1994,
Pubmed
,
Xenbase
Taglialatela,
Regulation of K+/Rb+ selectivity and internal TEA blockade by mutations at a single site in K+ pores.
1993,
Pubmed
Vandenberg,
Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions.
1987,
Pubmed
Wagoner,
Cation permeation through the voltage-dependent potassium channel in the squid axon. Characteristics and mechanisms.
1987,
Pubmed
Wang,
Renal potassium channels and their regulation.
1992,
Pubmed
Woodhull,
Ionic blockage of sodium channels in nerve.
1973,
Pubmed
Yang,
Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.
1995,
Pubmed
,
Xenbase
Yellen,
Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.
1991,
Pubmed
Yool,
Alteration of ionic selectivity of a K+ channel by mutation of the H5 region.
1991,
Pubmed
,
Xenbase
