Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more 'modern', later diverging V2Rs, whereas more 'ancient', earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of Xenopus tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient v2r gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.
Dittrich,
Metamorphic remodeling of the olfactory organ of the African clawed frog, Xenopus laevis.
2016, Pubmed,
Xenbase
Dittrich,
Metamorphic remodeling of the olfactory organ of the African clawed frog, Xenopus laevis.
2016,
Pubmed
,
Xenbase
Freitag,
Two classes of olfactory receptors in Xenopus laevis.
1995,
Pubmed
,
Xenbase
Gliem,
Bimodal processing of olfactory information in an amphibian nose: odor responses segregate into a medial and a lateral stream.
2013,
Pubmed
,
Xenbase
Hansen,
Ultrastructure of the olfactory organ in the clawed frog, Xenopus laevis, during larval development and metamorphosis.
1998,
Pubmed
,
Xenbase
Hansen,
Correlation between olfactory receptor cell type and function in the channel catfish.
2003,
Pubmed
Hassenklöver,
Nucleotide-induced Ca2+ signaling in sustentacular supporting cells of the olfactory epithelium.
2008,
Pubmed
,
Xenbase
Higgs,
Neuronal turnover in the Xenopus laevis olfactory epithelium during metamorphosis.
2001,
Pubmed
,
Xenbase
Junek,
Activity correlation imaging: visualizing function and structure of neuronal populations.
2009,
Pubmed
,
Xenbase
Liberles,
Mammalian pheromones.
2014,
Pubmed
Manzini,
Response profiles to amino acid odorants of olfactory glomeruli in larval Xenopus laevis.
2007,
Pubmed
,
Xenbase
Mezler,
Expression of olfactory receptors during development in Xenopus laevis.
1999,
Pubmed
,
Xenbase
Mezler,
Characteristic features and ligand specificity of the two olfactory receptor classes from Xenopus laevis.
2001,
Pubmed
,
Xenbase
Niimura,
Olfactory receptor multigene family in vertebrates: from the viewpoint of evolutionary genomics.
2012,
Pubmed
Niimura,
Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods.
2005,
Pubmed
Sansone,
Trpc2 is expressed in two olfactory subsystems, the main and the vomeronasal system of larval Xenopus laevis.
2014,
Pubmed
,
Xenbase
Sansone,
Phospholipase C and diacylglycerol mediate olfactory responses to amino acids in the main olfactory epithelium of an amphibian.
2014,
Pubmed
,
Xenbase
Sato,
Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish.
2005,
Pubmed
Syed,
Ancestral amphibian v2rs are expressed in the main olfactory epithelium.
2013,
Pubmed
,
Xenbase
