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Xenopus tropicalis is rapidly being adopted as a model organism for developmental biology research and has enormous potential for increasing our understanding of how embryonic development is controlled. In recent years there has been a well-organized initiative within the Xenopus community, funded largely through the support of the National Institutes of Health in the US, to develop X. tropicalis as a new genetic model system with the potential to impact diverse fields of research. Concerted efforts have been made both to adapt established methodologies for use in X. tropicalis and to develop new techniques. A key resource to come out of these efforts is the genome sequence, produced by the US Department of Energy's Joint Genome Institute and made freely available to the community in draft form for the past three years. In this review, we focus on how advances in X. tropicalis genetics coupled with the sequencing of its genome are likely to form a foundation from which we can build a better understanding of the genetic control of vertebrate development and why, when we already have other vertebrate genetic models, we should want to develop genetic analysis in the frog.
Allen,
Transgenic Xenopus laevis embryos can be generated using phiC31 integrase.
2005, Pubmed,
Xenbase
Allen,
Transgenic Xenopus laevis embryos can be generated using phiC31 integrase.
2005,
Pubmed
,
Xenbase
Aparicio,
Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes.
1995,
Pubmed
Baroukh,
Comparative genomic analysis reveals a distant liver enhancer upstream of the COUP-TFII gene.
2005,
Pubmed
Berman,
Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome.
2002,
Pubmed
Blanchette,
Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression.
2006,
Pubmed
Chae,
Inducible control of tissue-specific transgene expression in Xenopus tropicalis transgenic lines.
2002,
Pubmed
,
Xenbase
Chen,
Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells.
2000,
Pubmed
Denissov,
Identification of novel functional TBP-binding sites and general factor repertoires.
2007,
Pubmed
Draper,
Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown.
2001,
Pubmed
,
Xenbase
Fisher,
Conservation of RET regulatory function from human to zebrafish without sequence similarity.
2006,
Pubmed
Goda,
Genetic screens for mutations affecting development of Xenopus tropicalis.
2006,
Pubmed
,
Xenbase
Grammer,
Identification of mutants in inbred Xenopus tropicalis.
2005,
Pubmed
,
Xenbase
Halfon,
(Re)modeling the transcriptional enhancer.
2006,
Pubmed
Hallikas,
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity.
2006,
Pubmed
Hamlet,
Tol2 transposon-mediated transgenesis in Xenopus tropicalis.
2006,
Pubmed
,
Xenbase
Heasman,
Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach.
2000,
Pubmed
,
Xenbase
Hirsch,
Xenopus tropicalis transgenic lines and their use in the study of embryonic induction.
2002,
Pubmed
,
Xenbase
Janssens,
Quantitative and predictive model of transcriptional control of the Drosophila melanogaster even skipped gene.
2006,
Pubmed
Kenwrick,
Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development.
2004,
Pubmed
,
Xenbase
Kolm,
Efficient hormone-inducible protein function in Xenopus laevis.
1995,
Pubmed
,
Xenbase
Kroll,
Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation.
1996,
Pubmed
,
Xenbase
Lettice,
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.
2002,
Pubmed
Loots,
rVISTA 2.0: evolutionary analysis of transcription factor binding sites.
2004,
Pubmed
Matys,
TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes.
2006,
Pubmed
Meyer,
From 2R to 3R: evidence for a fish-specific genome duplication (FSGD).
2005,
Pubmed
Noramly,
A gynogenetic screen to isolate naturally occurring recessive mutations in Xenopus tropicalis.
2005,
Pubmed
,
Xenbase
Offield,
The development of Xenopus tropicalis transgenic lines and their use in studying lens developmental timing in living embryos.
2000,
Pubmed
,
Xenbase
Ogino,
Highly efficient transgenesis in Xenopus tropicalis using I-SceI meganuclease.
2006,
Pubmed
,
Xenbase
Palin,
Locating potential enhancer elements by comparative genomics using the EEL software.
2006,
Pubmed
Pan,
I-SceI meganuclease-mediated transgenesis in Xenopus.
2006,
Pubmed
,
Xenbase
Rajewsky,
Computational detection of genomic cis-regulatory modules applied to body patterning in the early Drosophila embryo.
2002,
Pubmed
Rana,
Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides.
2006,
Pubmed
,
Xenbase
Schroeder,
Transcriptional control in the segmentation gene network of Drosophila.
2004,
Pubmed
Shin,
Human-zebrafish non-coding conserved elements act in vivo to regulate transcription.
2005,
Pubmed
Sinha,
Stubb: a program for discovery and analysis of cis-regulatory modules.
2006,
Pubmed
Sinner,
Global analysis of the transcriptional network controlling Xenopus endoderm formation.
2006,
Pubmed
,
Xenbase
Sivak,
FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation.
2005,
Pubmed
,
Xenbase
Stemple,
TILLING--a high-throughput harvest for functional genomics.
2004,
Pubmed
Stewart,
Chromatin immunoprecipitation for studying transcriptional regulation in Xenopus oocytes and tadpoles.
2006,
Pubmed
,
Xenbase
Tada,
Analysis of competence and of Brachyury autoinduction by use of hormone-inducible Xbra.
1997,
Pubmed
,
Xenbase
Tartaglia,
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.
2001,
Pubmed
Tartaglia,
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
2003,
Pubmed
Taverner,
Microarray-based identification of VegT targets in Xenopus.
2005,
Pubmed
,
Xenbase
Tomlinson,
Xenopus as a model organism in developmental chemical genetic screens.
2005,
Pubmed
,
Xenbase
Vlieghe,
A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.
2006,
Pubmed
Wardle,
Zebrafish promoter microarrays identify actively transcribed embryonic genes.
2006,
Pubmed
Wasserman,
Applied bioinformatics for the identification of regulatory elements.
2004,
Pubmed
Waterston,
Initial sequencing and comparative analysis of the mouse genome.
2002,
Pubmed
Wienholds,
Target-selected inactivation of the zebrafish rag1 gene.
2002,
Pubmed
Woolfe,
Highly conserved non-coding sequences are associated with vertebrate development.
2005,
Pubmed
Yuh,
Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene.
1998,
Pubmed
Yuh,
Complexity and organization of DNA-protein interactions in the 5'-regulatory region of an endoderm-specific marker gene in the sea urchin embryo.
1994,
Pubmed
