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XB-ART-51354
Sci Signal 2015 Oct 06;8397:fs17. doi: 10.1126/scisignal.aad2816.
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Putting it all on pigmentation: Heuristics of a bold and stochastic cell fate decision.

Xing J , Lee RE .


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Gradients of transmembrane potential coordinate cell-fate decisions and patterning during embryogenesis and wound-healing. Bioelectrical signaling may also be more important for adult pathologies than currently recognized. In this issue of Science Signaling, Lobikin et al. describe a role for bioelectric signals during the development of Xenopus leavis embryos to instruct an organism-level response reminiscent of neoplastic progression in melanoma.

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Species referenced: Xenopus laevis
Genes referenced: tbx2

References :
Lobikin, Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network for stochastic all-or-none hyperpigmentation. 2015, Pubmed, Xenbase