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XB-ART-49869
Curr Biol 2013 Nov 18;2322:R1014-R1016. doi: 10.1016/j.cub.2013.10.003.
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Development: sketch for a theory of Oct4.

Wagner RT , Zwaka TP .


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How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.

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Species referenced: Xenopus
Genes referenced: pou5f3 sox2

References :
Livigni, A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance. 2013, Pubmed, Xenbase