Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor.
Klein-Hitpass L
,
Ryffel GU
,
Heitlinger E
,
Cato AC
.
???displayArticle.abstract???
Sequences located upstream of the transcription initiation site of the Xenopus vitellogenin A2 (vit A2) gene contain a hormone dependent enhancer that confers estrogen control to the heterologous thymidine kinase (tk) promoter. As a minimal functional estrogen responsive element (ERE), we have defined the 13 bp palindrome GGTCACAGTGACC. This ERE binds estrogen receptor preferentially in vitro. Although the ERE shares some structural features with the glucocorticoid responsive element (GRE) it is distinct from this element since it neither binds glucocorticoid receptor in vitro nor does it confer glucocorticoid inducibility to a fusion gene. Point mutations within the ERE decrease its affinity for the estrogen receptor and result in a complete loss of estrogen inducibility.
Beato,
Glucocorticoid-binding proteins of rat liver cytosol. I. Separation and identification of the binding proteins.
1972, Pubmed
Beato,
Glucocorticoid-binding proteins of rat liver cytosol. I. Separation and identification of the binding proteins.
1972,
Pubmed
Becker,
In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone.
,
Pubmed
Buetti,
Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.
1983,
Pubmed
Burch,
Identification and sequence analysis of the 5' end of the major chicken vitellogenin gene.
1984,
Pubmed
Cato,
The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.
1986,
Pubmed
Chandler,
DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.
1983,
Pubmed
Chen,
Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.
1985,
Pubmed
Danesch,
Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements.
1987,
Pubmed
Dean,
A 5'-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene.
,
Pubmed
Dente,
pEMBL: a new family of single stranded plasmids.
1983,
Pubmed
Druege,
Introduction of estrogen-responsiveness into mammalian cell lines.
1986,
Pubmed
,
Xenbase
Geiser,
Structure and sequence of the promoter area and of a 5' upstream demethylation site of the estrogen-regulated chicken vitellogenin ii gene.
1983,
Pubmed
Gorman,
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
1982,
Pubmed
Green,
A superfamily of potentially oncogenic hormone receptors.
,
Pubmed
Jantzen,
Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene.
1987,
Pubmed
Jones,
Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro.
1985,
Pubmed
Jost,
Preferential binding of estrogen-receptor complex to a region containing the estrogen-dependent hypomethylation site preceding the chicken vitellogenin II gene.
1984,
Pubmed
Karin,
Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.
,
Pubmed
Khoury,
Enhancer elements.
1983,
Pubmed
Klein-Hitpass,
An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells.
1986,
Pubmed
,
Xenbase
Klock,
Oestrogen and glucocorticoid responsive elements are closely related but distinct.
,
Pubmed
Lai,
Regulated expression of the chicken ovalbumin gene in a human estrogen-responsive cell line.
1983,
Pubmed
Melton,
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
1984,
Pubmed
Miksicek,
Glucocorticoid responsiveness of the transcriptional enhancer of Moloney murine sarcoma virus.
1986,
Pubmed
Ott,
Tissue-specific expression is conferred by a sequence from the 5' end of the rat albumin gene.
1984,
Pubmed
Pfahl,
Specific binding of the glucocorticoid-receptor complex to the mouse mammary tumor proviral promoter region.
1982,
Pubmed
Ponta,
Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties.
1985,
Pubmed
Renkawitz,
Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding.
1984,
Pubmed
Robins,
Regulated expression of human growth hormone genes in mouse cells.
1982,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Scheidereit,
The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus.
,
Pubmed
Scheidereit,
Molecular model of the interaction between the glucocorticoid receptor and the regulatory elements of inducible genes.
1986,
Pubmed
Seiler-Tuyns,
Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line.
1986,
Pubmed
,
Xenbase
ten Heggeler-Bordier,
Electron microscopic visualization of protein-DNA interactions at the estrogen responsive element and in the first intron of the Xenopus laevis vitellogenin gene.
1987,
Pubmed
,
Xenbase
von der Ahe,
Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters.
,
Pubmed
Wahli,
Xenopus vitellogenin genes.
1985,
Pubmed
,
Xenbase
Walker,
Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes.
1984,
Pubmed
,
Xenbase
Westphal,
The activated glucocorticoid receptor of rat liver. Purification and physical characterization.
1980,
Pubmed
Zinn,
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene.
1983,
Pubmed
