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Mitogen-activated protein kinase activation down-regulates a mechanism that inactivates cyclin B-cdc2 kinase in G2-arrested oocytes.
Abrieu A
,
Dorée M
,
Picard A
.
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The G2 arrest of oocytes from frogs, clams, and starfish requires that preformed cyclin B-cdc2 complexes [prematuration-promoting factor (MPF)] be kept in an inactive form that is largely due to inhibitory phosphorylation of this pre-MPF. We have investigated the role of mitogen-activated protein (MAP) kinase in the activation of this pre-MPF. The cytoplasm of both frog and starfish oocytes contains an activity that can rapidly inactivate injected MPF. When the MAP kinase of G2-arrested starfish or Xenopus oocytes was prematurely activated by microinjection of c-mos or Ste-11 delta N fusion proteins, the rate and extent of MPF inactivation was much reduced. Both effects were suppressed by expression of the specific MAP kinase phosphatase Pyst 1. These results show that MAP kinase down-regulates a mechanism that inactivates cyclin B-cdc2 kinase in Xenopus oocytes. In starfish oocytes, however, MAP kinase activation occurs only after germinal vesicle breakdown, much after MPF activation. In this case, down-regulation of the cyclin B-cdc2 inhibiting pathway is a sensitive response to hormonal stimulation that does not require MAP kinase activation.
Atherton-Fessler,
Cell cycle regulation of the p34cdc2 inhibitory kinases.
1994, Pubmed,
Xenbase
Atherton-Fessler,
Cell cycle regulation of the p34cdc2 inhibitory kinases.
1994,
Pubmed
,
Xenbase
Coleman,
Cdc2 regulatory factors.
1994,
Pubmed
Den Haese,
The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2.
1995,
Pubmed
Devault,
Concerted roles of cyclin A, cdc25+ mitotic inducer, and type 2A phosphatase in activating the cyclin B/cdc2 protein kinase at the G2/M phase transition.
1991,
Pubmed
,
Xenbase
Dorée,
The cyclin-dependent protein kinases and the control of cell division.
1994,
Pubmed
Featherstone,
Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase.
1991,
Pubmed
Gabrielli,
Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex.
1992,
Pubmed
,
Xenbase
Galas,
A nuclear factor required for specific translation of cyclin B may control the timing of first meiotic cleavage in starfish oocytes.
1993,
Pubmed
Gautier,
Dephosphorylation and activation of Xenopus p34cdc2 protein kinase during the cell cycle.
1989,
Pubmed
,
Xenbase
Gotoh,
Initiation of Xenopus oocyte maturation by activation of the mitogen-activated protein kinase cascade.
1995,
Pubmed
,
Xenbase
Gould,
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis.
1989,
Pubmed
Groom,
Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.
1996,
Pubmed
,
Xenbase
Guerrier,
Hormonal control of reinitiation of meiosis in starfish. The requirement of 1-methyladenine during nuclear maturation.
1975,
Pubmed
Huang,
Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system.
1996,
Pubmed
,
Xenbase
Kamps,
Generation and use of anti-phosphotyrosine antibodies for immunoblotting.
1991,
Pubmed
Kanatani,
Isolation and indentification on meiosis inducing substance in starfish Asterias amurensis.
1969,
Pubmed
Kishimoto,
Role of germinal vesicle material in producing maturation-promoting factor in starfish oocyte.
1981,
Pubmed
Kishimoto,
Cytoplasmic factor responsible for germinal vesicle breakdown and meiotic maturation in starfish oocyte.
1976,
Pubmed
Kornbluth,
Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14.
1994,
Pubmed
,
Xenbase
Kosako,
Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.
1994,
Pubmed
,
Xenbase
Kosako,
Regulation and function of the MAP kinase cascade in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Labbe,
Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation.
1989,
Pubmed
,
Xenbase
Labbé,
M phase-specific cdc2 kinase: preparation from starfish oocytes and properties.
1991,
Pubmed
,
Xenbase
Lee,
Inhibition of cdc2 activation by INH/PP2A.
1994,
Pubmed
,
Xenbase
Lorca,
Cyclin A-cdc2 kinase does not trigger but delays cyclin degradation in interphase extracts of amphibian eggs.
1992,
Pubmed
,
Xenbase
Lundgren,
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2.
1991,
Pubmed
Maina,
An Escherichia coli vector to express and purify foreign proteins by fusion to and separation from maltose-binding protein.
1988,
Pubmed
Masui,
Oocyte maturation.
1979,
Pubmed
Mueller,
Cell cycle regulation of a Xenopus Wee1-like kinase.
1995,
Pubmed
,
Xenbase
Nebreda,
The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.
1993,
Pubmed
,
Xenbase
Nebreda,
Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Nurse,
Universal control mechanism regulating onset of M-phase.
1990,
Pubmed
Okumura,
Initial triggering of M-phase in starfish oocytes: a possible novel component of maturation-promoting factor besides cdc2 kinase.
1996,
Pubmed
Picard,
Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase.
1991,
Pubmed
,
Xenbase
Picard,
The cell cycle can occur in starfish oocytes and embryos without the production of transferable MPF (maturation-promoting factor).
1988,
Pubmed
Picard,
The role of the germinal vesicle in producing maturation-promoting factor (MPF) as revealed by the removal and transplantation of nuclear material in starfish oocytes.
1984,
Pubmed
Picard,
Lithium inhibits amplification or action of the maturation-promoting factor (MPF) in meiotic maturation of starfish oocytes.
1983,
Pubmed
Picard,
Newly assembled cyclin B-cdc2 kinase is required to suppress DNA replication between meiosis I and meiosis II in starfish oocytes.
1996,
Pubmed
Pickham,
Mutants at Ser277 of Xenopus cdc2 protein kinase induce oocyte maturation in the absence of the positive regulatory phosphorylation site Thr161.
1994,
Pubmed
,
Xenbase
Russell,
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.
1987,
Pubmed
Sagata,
The product of the mos proto-oncogene as a candidate "initiator" for oocyte maturation.
1989,
Pubmed
,
Xenbase
Sagata,
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
Shibuya,
Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.
1992,
Pubmed
Solomon,
Cyclin activation of p34cdc2.
1990,
Pubmed
,
Xenbase
Strausfeld,
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein.
1991,
Pubmed
Verlhac,
Microtubule and chromatin behavior follow MAP kinase activity but not MPF activity during meiosis in mouse oocytes.
1994,
Pubmed
,
Xenbase
