XB-ART-15161
Proc Natl Acad Sci U S A
1998 Mar 17;956:2938-43. doi: 10.1073/pnas.95.6.2938.
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Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex.
Nolte RT
,
Conlin RM
,
Harrison SC
,
Brown RS
.
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The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.
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Species referenced: Xenopus laevis
Genes referenced: gtf3a
References [+] :
,
The CCP4 suite: programs for protein crystallography.
2004, Pubmed
, The CCP4 suite: programs for protein crystallography. 2004, Pubmed
Arakawa, Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. 1995, Pubmed , Xenbase
Archambault, The deduced sequence of the transcription factor TFIIIA from Saccharomyces cerevisiae reveals extensive divergence from Xenopus TFIIIA. 1992, Pubmed , Xenbase
Berg, Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins. 1988, Pubmed
Brown, The primary structure of transcription factor TFIIIA has 12 consecutive repeats. 1985, Pubmed , Xenbase
Carson, Ribbons. 1997, Pubmed
Choo, A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA. 1993, Pubmed
Clemens, Definition of the binding sites of individual zinc fingers in the transcription factor IIIA-5S RNA gene complex. 1992, Pubmed , Xenbase
Clemens, Relative contributions of the zinc fingers of transcription factor IIIA to the energetics of DNA binding. 1994, Pubmed , Xenbase
Conlin, Reconstitution of protein-DNA complexes for crystallization. 1994, Pubmed , Xenbase
Elrod-Erickson, Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions. 1996, Pubmed
Engelke, Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes. 1980, Pubmed , Xenbase
Fairall, Mapping of the sites of protection on a 5 S RNA gene by the Xenopus transcription factor IIIA. A model for the interaction. 1986, Pubmed , Xenbase
Fairall, The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition. 1993, Pubmed
Forget, The nucleotide sequence of ribosomal 5 S ribonucleic acid from KB cells. 1969, Pubmed
Foster, Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA. 1997, Pubmed
Fridell, Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev. 1996, Pubmed , Xenbase
Gaskins, Sequence variation in transcription factor IIIA. 1990, Pubmed , Xenbase
Gaskins, Comparison of the sequence and structure of transcription factor IIIA from Bufo americanus and Rana pipiens. 1992, Pubmed , Xenbase
Ginsberg, Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development. 1984, Pubmed , Xenbase
Greisman, A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. 1997, Pubmed
Hanas, Structure, function, evolution of transcription factor IIIA. 1992, Pubmed
Hayes, Structure of the TFIIIA-5 S DNA complex. 1992, Pubmed , Xenbase
Houbaviy, Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. 1996, Pubmed
Kim, A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA. 1996, Pubmed
Korn, Nucleotide sequence of Xenopus borealis oocyte 5S DNA: comparison of sequences that flank several related eucaryotic genes. 1978, Pubmed , Xenbase
Lavery, Defining the structure of irregular nucleic acids: conventions and principles. 1989, Pubmed
Lee, Three-dimensional solution structure of a single zinc finger DNA-binding domain. 1989, Pubmed , Xenbase
Mao, A position-dependent transcription-activating domain in TFIIIA. 1993, Pubmed , Xenbase
Maxwell, Complementarity of sequences in low molecular weight RNAs to regions of messenger and ribosomal RNAs. 1986, Pubmed
McConkey, Transition mutations within the Xenopus borealis somatic 5S RNA gene can have independent effects on transcription and TFIIIA binding. 1987, Pubmed , Xenbase
Miller, Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. 1985, Pubmed , Xenbase
Nekludova, Distinctive DNA conformation with enlarged major groove is found in Zn-finger-DNA and other protein-DNA complexes. 1994, Pubmed
Ogilvie, Molecular biology of vertebrate transcription factor IIIA: cloning and characterization of TFIIIA from channel catfish oocytes. 1997, Pubmed , Xenbase
Otwinowski, Processing of X-ray diffraction data collected in oscillation mode. 1997, Pubmed
Pavletich, Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. 1991, Pubmed
Pavletich, Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. 1993, Pubmed
Pelham, A specific transcription factor that can bind either the 5S RNA gene or 5S RNA. 1980, Pubmed , Xenbase
Picard, Isolation of a 7S particle from Xenopus laevis oocytes: a 5S RNA-protein complex. 1979, Pubmed , Xenbase
Pieler, TFIIIA: nine fingers--three hands? 1993, Pubmed , Xenbase
Pieler, Functional domains of the Xenopus laevis 5S gene promoter. 1985, Pubmed , Xenbase
Rawlings, Analysis of the binding of Xenopus transcription factor IIIA to oocyte 5 S rRNA and to the 5 S rRNA gene. 1996, Pubmed , Xenbase
Rowland, Interaction of wild-type and truncated forms of transcription factor IIIA from Saccharomyces cerevisiae with the 5 S RNA gene. 1996, Pubmed
Sakonju, Contact points between a positive transcription factor and the Xenopus 5S RNA gene. 1982, Pubmed , Xenbase
Shastry, Transcription factor IIIA (TFIIIA) in the second decade. 1996, Pubmed , Xenbase
Smith, Structural elements in the N-terminal half of transcription factor IIIA required for factor binding to the 5S RNA gene internal control region. 1991, Pubmed , Xenbase
Taylor, The developmental expression of the gene for TFIIIA in Xenopus laevis. 1986, Pubmed , Xenbase
Valenzuela, Nucleotide sequence of the yeast 5S ribosomal RNA gene and adjacent putative control regions. 1977, Pubmed
Veldhoen, Contribution of individual base pairs to the interaction of TFIIIA with the Xenopus 5S RNA gene. 1994, Pubmed , Xenbase
Wegnez, Sequence heterogeneity of 5 S RNA in Xenopus laevis. 1972, Pubmed , Xenbase
Wuttke, Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity. 1997, Pubmed , Xenbase
Zang, Effects of zinc finger mutations on the nucleic acid binding activities of Xenopus transcription factor IIIA. 1995, Pubmed , Xenbase
Zwieb, Absence of substantial bending in Xenopus laevis transcription factor IIIA-DNA complexes. 1990, Pubmed , Xenbase