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Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.
Malik TH
,
Shoichet SA
,
Latham P
,
Kroll TG
,
Peters LL
,
Shivdasani RA
.
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Known vertebrate GATA proteins contain two zinc fingers and are required in development, whereas invertebrates express a class of essential proteins containing one GATA-type zinc finger. We isolated the gene encoding TRPS1, a vertebrate protein with a single GATA-type zinc finger. TRPS1 is highly conserved between Xenopus and mammals, and the human gene is implicated in dominantly inherited tricho-rhino-phalangeal (TRP) syndromes. TRPS1 is a nuclear protein that binds GATA sequences but fails to transactivate a GATA-dependent reporter. Instead, TRPS1 potently and specifically represses transcriptional activation mediated by other GATA factors. Repression does not occur from competition for DNA binding and depends on a C-terminal region related to repressive domains found in Ikaros proteins. During mouse development, TRPS1 expression is prominent in sites showing pathology in TRP syndromes, which are thought to result from TRPS1 haploinsufficiency. We show instead that truncating mutations identified in patients encode dominant inhibitors of wild-type TRPS1 function, suggesting an alternative mechanism for the disease. TRPS1 is the first example of a GATA protein with intrinsic transcriptional repression activity and possibly a negative regulator of GATA-dependent processes in vertebrate development.
Cubadda,
u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila.
1997, Pubmed
Cubadda,
u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila.
1997,
Pubmed
da Costa,
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.
1999,
Pubmed
Deconinck,
FOG acts as a repressor of red blood cell development in Xenopus.
2000,
Pubmed
,
Xenbase
Fukushige,
The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine.
1998,
Pubmed
Georgopoulos,
The role of the Ikaros gene in lymphocyte development and homeostasis.
1997,
Pubmed
Haenlin,
Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila.
1997,
Pubmed
Henry,
Mixer, a homeobox gene required for endoderm development.
1998,
Pubmed
,
Xenbase
Holmes,
hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation.
1999,
Pubmed
Kim,
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.
1999,
Pubmed
Ko,
DNA-binding specificities of the GATA transcription factor family.
1993,
Pubmed
Koipally,
Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.
1999,
Pubmed
Koutsourakis,
The transcription factor GATA6 is essential for early extraembryonic development.
1999,
Pubmed
Kroll,
PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
2000,
Pubmed
Kuo,
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
1997,
Pubmed
Langer,
The tricho-rhino-phalangeal syndrome with exostoses (or Langer-Giedion syndrome): four additional patients without mental retardation and review of the literature.
1984,
Pubmed
Laverriere,
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
1994,
Pubmed
Lüdecke,
Genotypic and phenotypic spectrum in tricho-rhino-phalangeal syndrome types I and III.
2001,
Pubmed
Malik,
Structure and expression of a novel frizzled gene isolated from the developing mouse gut.
2000,
Pubmed
Martin,
Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.
1990,
Pubmed
Mead,
Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins.
1998,
Pubmed
,
Xenbase
Merika,
DNA-binding specificity of GATA family transcription factors.
1993,
Pubmed
Molkentin,
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
1997,
Pubmed
Molkentin,
The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.
2000,
Pubmed
Momeni,
Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I.
2000,
Pubmed
Omichinski,
NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1.
1993,
Pubmed
Pevny,
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1.
1991,
Pubmed
Reiter,
Gata5 is required for the development of the heart and endoderm in zebrafish.
1999,
Pubmed
,
Xenbase
Reuter,
The gene serpent has homeotic properties and specifies endoderm versus ectoderm within the Drosophila gut.
1994,
Pubmed
Rowe,
Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
1994,
Pubmed
Shi,
Thyroid hormone-dependent regulation of the intestinal fatty acid-binding protein gene during amphibian metamorphosis.
1994,
Pubmed
,
Xenbase
Shivdasani,
The transcriptional control of hematopoiesis.
1996,
Pubmed
Shivdasani,
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development.
1997,
Pubmed
Shizuya,
Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.
1992,
Pubmed
Shoichet,
Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates.
2000,
Pubmed
,
Xenbase
Svensson,
A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription.
2000,
Pubmed
Svensson,
A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2.
2000,
Pubmed
,
Xenbase
Svensson,
Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes.
1999,
Pubmed
Tevosian,
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
1999,
Pubmed
Tevosian,
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
2000,
Pubmed
Ting,
Transcription factor GATA-3 is required for development of the T-cell lineage.
1996,
Pubmed
Tsai,
An early haematopoietic defect in mice lacking the transcription factor GATA-2.
1994,
Pubmed
Tsang,
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.
1997,
Pubmed
Tsang,
Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG.
1998,
Pubmed
Turner,
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
1994,
Pubmed
,
Xenbase
Weber,
A role for GATA5 in Xenopus endoderm specification.
2000,
Pubmed
,
Xenbase
Yang,
Distinct roles for the two cGATA-1 finger domains.
1992,
Pubmed
Zhang,
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.
1999,
Pubmed
Zhu,
end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos.
1997,
Pubmed
,
Xenbase
