Neurosci Lett 1995 Apr 21;1893:155-8. doi: 10.1016/0304-3940(95)11479-g.

Localization of the rho 1- and rho 2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of gamma-aminobutyric acid type C receptor subtypes.

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We have amplified partial complementary DNAs for the chicken gamma-aminobutyric acid type C (GABAC) receptor rho 1 and rho 2 subunits using the polymerase chain reaction. These nucleotide sequences have been utilized to design specific oligonucleotide probes for the in situ hybridization localization of the corresponding messenger RNAs (mRNAs) in the 1-day-old chick retina. Although both transcripts are found almost exclusively in the inner nuclear layer, their distributions differ markedly. From the locations of the hybridization signals, we deduce that the rho 1-subunit mRNA is present mainly in bipolar cells and that the rho 2-subunit mRNA is present in both amacrine and horizontal cells. These results suggest that the rho 1 and rho 2 subunits frequently occur in different receptor complexes and, therefore, that subtypes of the GABAC receptor exist.

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Species referenced: Xenopus laevis
Genes referenced: rho rho.2