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XB-ART-21035
FEBS Lett 1994 Jul 18;3483:239-43.
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Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.

Tang W , Yang XC .


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We have cloned a novel inward rectifier K+ channel (hIRK2) from a human frontal cortex cDNA library. The amino acid sequence of hIRK2 shares 60% and 40% identity with the mouse IRK1 and the rat ROMK1 channels, respectively. Xenopus oocytes injected with hIRK2 cRNA showed an inwardly rectifying K+ current that had a prominent 'N-shape' I-V curve and was blocked by extracellular Ba2+. The hIRK2 channel has two unique features: (a) an 18 amino acid insertion between the first transmembrane region and the pore, and (b) restricted mRNA distribution found only in human brain and heart.

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Species referenced: Xenopus
Genes referenced: kcnj1 kcnj2 kcnj4