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XB-ART-40336
Biochem Biophys Res Commun 2009 Dec 11;3902:211-6. doi: 10.1016/j.bbrc.2009.09.086.
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The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.

van Wijk NV , Witte F , Feike AC , Schambony A , Birchmeier W , Mundlos S , Stricker S .


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Wtip is a LIM domain protein of the Ajuba/Zyxin family involved in kidney and neural crest development; Ror2 is a receptor tyrosine kinase involved in the development of skeleton, heart, lung, genitalia and kidneys. Here we describe Wtip as an intracellular interaction partner of Ror2. Full-length Ror2 recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo. We show that Wtip is able to inhibit canonical Wnt signalling in mammalian cells and in Xenopus embryos linking Wtip to a crucial developmental pathway.

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Species referenced: Xenopus
Genes referenced: bmpr1b dvl2 flna gsk3a ror2 wnt8a wt1 wtip zyx
GO keywords: axis specification [+]


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