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???displayArticle.abstract??? Fatvg is a localized maternal transcript that translocates to the vegetal cortex of Xenopus laevis oocytes through both the METRO and Late RNA localization pathways. It is a member of a gene family that functions in vesicular trafficking. Depletion of the maternal store of fatvg mRNA results in a dual phenotype in which embryos are ventralized and also lack primordial germ cells. This complex fatvg loss of function phenotype is the result of stabilization of the dorsalizing factor beta-catenin at the vegetal pole and the inability of the germ cell determinants to move to their proper locations. This is coincident with the inhibition of cortical rotation and the abnormal aggregation of the germ plasm. Fatvg protein is located at the periphery of vesicles in the oocyte and embryo, supporting its proposed role in vesicular trafficking in the embryo. These results point to a common fundamental mechanism that is regulated by fatvg through which germ cell determinants and dorsalizing factors segregate during early development.
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al-Mukhtar,
An ultrastructural study of primordial germ cells, oogonia and early oocytes in Xenopus laevis.
1971, Pubmed,
Xenbase
al-Mukhtar,
An ultrastructural study of primordial germ cells, oogonia and early oocytes in Xenopus laevis.
1971,
Pubmed
,
Xenbase
Basyuk,
Retroviral genomic RNAs are transported to the plasma membrane by endosomal vesicles.
2003,
Pubmed
Birsoy,
Vg 1 is an essential signaling molecule in Xenopus development.
2006,
Pubmed
,
Xenbase
BLACKLER,
Contribution to the study of germ-cells in the anura.
1958,
Pubmed
Brasaemle,
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein.
1997,
Pubmed
Buehr,
Sterility and partial sterility in the South African clawed toad following the pricking of the egg.
1970,
Pubmed
Chan,
fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes.
1999,
Pubmed
,
Xenbase
Chan,
The vegetally localized mRNA fatvg is associated with the germ plasm in the early embryo and is later expressed in the fat body.
2001,
Pubmed
,
Xenbase
Coggins,
An ultrastructural and radioautographic study of early oogenesis in the toad Xenopus laevis.
1973,
Pubmed
,
Xenbase
Czolowska,
Observations on the origin of the 'germinal cytoplasm' in Xenopus laevis.
1969,
Pubmed
,
Xenbase
Czołowska,
The fine structure of the "germinal cytoplasm" in the egg ofXenopus laevis.
1972,
Pubmed
Deshler,
Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum.
1997,
Pubmed
,
Xenbase
Díaz,
TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking.
1998,
Pubmed
Dominguez,
Dorsal downregulation of GSK3beta by a non-Wnt-like mechanism is an early molecular consequence of cortical rotation in early Xenopus embryos.
2000,
Pubmed
,
Xenbase
Elinson,
Two UV-sensitive targets in dorsoanterior specification of frog embryos.
1989,
Pubmed
,
Xenbase
Etkin,
A new face for the endoplasmic reticulum: RNA localization.
1997,
Pubmed
,
Xenbase
Farr,
Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.
2000,
Pubmed
,
Xenbase
Forristall,
Patterns of localization and cytoskeletal association of two vegetally localized RNAs, Vg1 and Xcat-2.
1995,
Pubmed
,
Xenbase
Fujisue,
Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotation.
1993,
Pubmed
,
Xenbase
Grant,
The amphibian gray crescent region--a site of developmental information?
1972,
Pubmed
Heasman,
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.
1994,
Pubmed
,
Xenbase
Heasman,
The mitochondrial cloud of Xenopus oocytes: the source of germinal granule material.
1984,
Pubmed
,
Xenbase
Heasman,
Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach.
2000,
Pubmed
,
Xenbase
Heid,
Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases.
1998,
Pubmed
Holowacz,
Cortical cytoplasm, which induces dorsal axis formation in Xenopus, is inactivated by UV irradiation of the oocyte.
1993,
Pubmed
,
Xenbase
Horb,
A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation.
1997,
Pubmed
,
Xenbase
Houston,
A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus.
2000,
Pubmed
,
Xenbase
Houston,
Germ plasm and molecular determinants of germ cell fate.
2000,
Pubmed
,
Xenbase
Hudson,
Xpat, a gene expressed specifically in germ plasm and primordial germ cells of Xenopus laevis.
1998,
Pubmed
,
Xenbase
Ijiri,
Existence of ultraviolet-labile germ cell determinant in unfertilized eggs of Xenopus laevis and its sensitivity.
1977,
Pubmed
,
Xenbase
Jiang,
Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein.
1992,
Pubmed
Joseph,
Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos.
1998,
Pubmed
,
Xenbase
Kao,
Generation of body plan phenotypes in early embryogenesis.
1991,
Pubmed
,
Xenbase
Kloc,
Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Kloc,
RNA localization and germ cell determination in Xenopus.
2001,
Pubmed
,
Xenbase
Kloc,
Mechanisms of subcellular mRNA localization.
2002,
Pubmed
Kloc,
Contribution of METRO pathway localized molecules to the organization of the germ cell lineage.
1998,
Pubmed
,
Xenbase
Kofron,
Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin.
2007,
Pubmed
,
Xenbase
Kofron,
Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors.
1999,
Pubmed
,
Xenbase
Larabell,
Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway.
1997,
Pubmed
,
Xenbase
Lustig,
Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation.
1996,
Pubmed
,
Xenbase
Miller,
Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation.
1999,
Pubmed
,
Xenbase
Rebagliati,
Identification and cloning of localized maternal RNAs from Xenopus eggs.
1985,
Pubmed
,
Xenbase
Ressom,
Relocation and reorganization of germ plasm in Xenopus embryos after fertilization.
1988,
Pubmed
,
Xenbase
Robb,
A kinesin-like protein is required for germ plasm aggregation in Xenopus.
1996,
Pubmed
,
Xenbase
Rowning,
Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs.
1997,
Pubmed
,
Xenbase
Ryan,
Eomesodermin, a key early gene in Xenopus mesoderm differentiation.
1996,
Pubmed
,
Xenbase
Savage,
Dynamics of germ plasm localization and its inhibition by ultraviolet irradiation in early cleavage Xenopus embryos.
1993,
Pubmed
,
Xenbase
Smith,
The role of a "germinal plasm" in the formation of primordial germ cells in Rana pipiens.
1966,
Pubmed
Song,
Hermes RNA-binding protein targets RNAs-encoding proteins involved in meiotic maturation, early cleavage, and germline development.
2007,
Pubmed
,
Xenbase
Stennard,
The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation.
1996,
Pubmed
,
Xenbase
Tao,
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
2005,
Pubmed
,
Xenbase
Walmsley,
Negative control of Xenopus GATA-2 by activin and noggin with eventual expression in precursors of the ventral blood islands.
1994,
Pubmed
,
Xenbase
Weaver,
GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs.
2003,
Pubmed
,
Xenbase
Weeks,
A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.
1987,
Pubmed
,
Xenbase
Wolins,
TIP47 associates with lipid droplets.
2001,
Pubmed
Xanthos,
Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis.
2001,
Pubmed
,
Xenbase
Yost,
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.
1998,
Pubmed
,
Xenbase
Zhang,
Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning.
1996,
Pubmed
,
Xenbase
Zhang,
The role of maternal VegT in establishing the primary germ layers in Xenopus embryos.
1998,
Pubmed
,
Xenbase
Züst,
The effect of u.v. irradiation of the vegetal pole of Xenopus laevis eggs on the presumptive primordial germ cells.
1975,
Pubmed
,
Xenbase
