Barron SC , McLaughlin JT , See JA , Richards VL , Rosenberg RL .

DA017882 NIDA NIH HHS

Akabas, Acetylcholine receptor channel structure probed in cysteine-substitution mutants. 1992, Pubmed, Xenbase

Akabas, Acetylcholine receptor channel structure probed in cysteine-substitution mutants. 1992, Pubmed , Xenbase
Amin, Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors. 1997, Pubmed , Xenbase
Bertrand, Allosteric modulation of nicotinic acetylcholine receptors. 2007, Pubmed
Bertrand, Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment. 2008, Pubmed , Xenbase
Bianchi, Mutation of the 9' leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states. 2001, Pubmed
Bouzat, Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel. 2004, Pubmed
Brejc, Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. 2001, Pubmed
Celie, Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. 2004, Pubmed
Chang, Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism. 2002, Pubmed , Xenbase
Colquhoun, Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. 1998, Pubmed
Filatov, The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating. 1995, Pubmed , Xenbase
Galzi, Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor. 1996, Pubmed , Xenbase
Gay, Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening. 2007, Pubmed
Gay, Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization. 2008, Pubmed , Xenbase
Gotti, Neuronal nicotinic receptors: from structure to pathology. 2004, Pubmed
Grønlien, Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. 2007, Pubmed , Xenbase
Günther, Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. 1995, Pubmed
Hansen, Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. 2005, Pubmed
Hurst, A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. 2005, Pubmed , Xenbase
Jackson, Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor. 1989, Pubmed
Karlin, Emerging structure of the nicotinic acetylcholine receptors. 2002, Pubmed
Lansdell, RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. 2005, Pubmed , Xenbase
Lyford, Agonist-induced conformational changes in the extracellular domain of alpha 7 nicotinic acetylcholine receptors. 2003, Pubmed , Xenbase
McLaughlin, Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors. 2006, Pubmed , Xenbase
McLaughlin, Agonist-driven conformational changes in the inner beta-sheet of alpha7 nicotinic receptors. 2007, Pubmed , Xenbase
McLaughlin, Conformational changes in alpha 7 acetylcholine receptors underlying allosteric modulation by divalent cations. 2009, Pubmed , Xenbase
Mihalak, Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors. 2006, Pubmed , Xenbase
Orr-Urtreger, Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. 1997, Pubmed
Pascual, State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit. 1998, Pubmed , Xenbase
Pless, Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. 2007, Pubmed , Xenbase
Purohit, Unliganded gating of acetylcholine receptor channels. 2009, Pubmed
Revah, Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. 1991, Pubmed , Xenbase
Sharkey, Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces. 2008, Pubmed , Xenbase
Timmermann, An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. 2007, Pubmed , Xenbase
Unwin, Refined structure of the nicotinic acetylcholine receptor at 4A resolution. 2005, Pubmed
Venkatachalan, A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics. 2008, Pubmed , Xenbase
Xiu, A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors. 2005, Pubmed , Xenbase
Young, Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. 2008, Pubmed , Xenbase
Zhang, Agonist- and antagonist-induced conformational changes of loop F and their contributions to the rho1 GABA receptor function. 2009, Pubmed , Xenbase
Zhong, From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. 1998, Pubmed