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XB-ART-19264
Biochem Biophys Res Commun 1995 Sep 14;2142:482-9. doi: 10.1006/bbrc.1995.2312.
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Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids.

Tamai I , Takanaga H , Maeda H , Sai Y , Ogihara T , Higashida H , Tsuji A .


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A molecular mechanism for the intestinal monocarboxylic acid transport was characterized by using a proton/monocarboxylate transporter, MCT1, in Chinese hamster ovary (CHO) cells, first found by Garcia et al. (Cell, 76, 865-873, 1994). Northern blotting analysis showed that MCT1-isomers exist in the rat and rabbit intestinal enterocytes and Caco-2 cells. The expression of [14C]lactic acid uptake by Xenopus laevis oocytes injected with rabbit intestinal mRNA was reduced by hybridizing the mRNA with a MCT1 cDNA of CHO cells before microinjection used as the antisense DNA. [14C]Lactic acid uptake by CHO cells was pH dependent, saturable, stereospecific, and reduced in the presence of acetic acid, benzoic acid, S- and R-ibuprofen, S- and R-mandelic acid, nicotinic acid, pravastatin, propionic acid and valproic acid. In addition, several monocarboxylic acids were transported in pH-dependent and saturable manners. These results suggest that the intestinal MCT1-related protein contributes to a carrier-mediated absorption for organic weak acid compounds.

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Species referenced: Xenopus laevis
Genes referenced: mcts1 slc16a1 tbx2