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Proc Natl Acad Sci U S A
1997 Jan 07;941:142-7. doi: 10.1073/pnas.94.1.142.
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A human protein related to yeast Cdc6p.
Williams RS
,
Shohet RV
,
Stillman B
.
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The unstable proteins Cdc6p and cdc18+ are essential and rate limiting for the initiation of DNA replication in Saccharomyces cerevisiae and Schizosaccharomyces pombe, respectively, and also participate in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. We have identified Xenopus and human proteins closely related to Cdc6p/cdc18. The human protein, p62(cdc6), is encoded on chromosome 17q21.3 and includes putative cyclin-dependent kinase phosphorylation sites, destruction boxes, a nucleotide binding/ATPase domain, and a potential leucine zipper. Expression of p62(cdc6) mRNA and protein is suppressed in human diploid fibroblasts made quiescent by serum starvation, and peaks as cells reenter the cell cycle and replicate DNA following serum stimulation. Conservation of structure among proteins involved in initiation suggests that fundamental features of replication complexes are maintained in all eukaryotes.
Amon,
Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.
1994, Pubmed
Amon,
Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.
1994,
Pubmed
Bassel-Duby,
Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes.
1994,
Pubmed
Bell,
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
1992,
Pubmed
Bell,
The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
1995,
Pubmed
Buchkovich,
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle.
1989,
Pubmed
Bueno,
Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division.
1992,
Pubmed
Carpenter,
Role for a Xenopus Orc2-related protein in controlling DNA replication.
1996,
Pubmed
,
Xenbase
Cocker,
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.
1996,
Pubmed
Coleman,
The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts.
1996,
Pubmed
,
Xenbase
Dahmann,
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state.
1995,
Pubmed
Diffley,
Two steps in the assembly of complexes at yeast replication origins in vivo.
1994,
Pubmed
,
Xenbase
Diffley,
Protein-DNA interactions at a yeast replication origin.
1992,
Pubmed
Diffley,
The initiation of DNA replication in the budding yeast cell division cycle.
1995,
Pubmed
Ehrenhofer-Murray,
Separation of origin recognition complex functions by cross-species complementation.
1995,
Pubmed
Gavin,
Conserved initiator proteins in eukaryotes.
1995,
Pubmed
Gossen,
A Drosophila homolog of the yeast origin recognition complex.
1995,
Pubmed
Grayson,
Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter.
1995,
Pubmed
Hartwell,
Sequential function of gene products relative to DNA synthesis in the yeast cell cycle.
1976,
Pubmed
Hogan,
Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.
1992,
Pubmed
Jallepalli,
Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe.
1996,
Pubmed
Jans,
Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells.
1995,
Pubmed
Johansson,
The TATA-less promoter of mouse ribonucleotide reductase R1 gene contains a TFII-I binding initiator element essential for cell cycle-regulated transcription.
1995,
Pubmed
Kelly,
The fission yeast cdc18+ gene product couples S phase to START and mitosis.
1993,
Pubmed
Kelly,
Coupling DNA replication to the cell cycle.
1993,
Pubmed
Landschulz,
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
1988,
Pubmed
Leatherwood,
Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein.
1996,
Pubmed
Liang,
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.
1995,
Pubmed
Lisziewicz,
Cloning and characterization of the Saccharomyces cerevisiae CDC6 gene.
1988,
Pubmed
Loo,
The origin recognition complex in silencing, cell cycle progression, and DNA replication.
1995,
Pubmed
Muzi Falconi,
cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.
1996,
Pubmed
Muzi-Falconi,
Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.
1995,
Pubmed
Nishitani,
p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast.
1995,
Pubmed
Ohtani,
Regulation of the cyclin E gene by transcription factor E2F1.
1995,
Pubmed
Piatti,
Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae.
1995,
Pubmed
Rao,
The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.
1995,
Pubmed
Rowles,
Interaction between the origin recognition complex and the replication licensing system in Xenopus.
1996,
Pubmed
,
Xenbase
Rowley,
Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
1995,
Pubmed
Studier,
Use of T7 RNA polymerase to direct expression of cloned genes.
1990,
Pubmed
Zhou,
Molecular cloning of Saccharomyces cerevisiae CDC6 gene. Isolation, identification, and sequence analysis.
1989,
Pubmed
Zwerschke,
The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation.
1994,
Pubmed
