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XB-ART-10141
Cancer Res 2000 Oct 01;6019:5386-9.
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Regulation of gli activity by all-trans retinoic acid in mouse keratinocytes.

Goyette P , Allan D , Peschard P , Chen CF , Wang W , Lohnes D .


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Sonic hedgehog (Shh) signaling is essential for many normal developmental processes. The Shh signal is interpreted by the Gli transcription factors. Elevated Gli-1 expression has been associated with several neoplasms, including basal cell carcinoma. All-trans retinoic acid (RA) has strong effects on epidermal growth and differentiation and has been used for the treatment of various epithelial disorders. In this report, we show that RA can inhibit Gli activity in immortalized murine keratinocytes in a RA receptor-specific manner. This inhibition may occur, at least in part, through sequestration of the transcriptional coactivator cyclic AMP-responsive element-binding protein-binding protein and suggests a novel effect of retinoid excess on Shh signaling.

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Species referenced: Xenopus
Genes referenced: gli1 shh