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XB-ART-10479
Curr Top Dev Biol 2000 Jan 01;50:45-60. doi: 10.1016/s0070-2153(00)50003-9.
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Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis.

Davidson AJ , Zon LI .


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The formation of hematopoietic stem cells during development occurs by a multistep process that begins with the induction of ventral mesoderm. This mesoderm is patterned during gastrulation by a bone morphogenetic protein (BMP) signaling pathway that is mediated, at least in part, by members of the Mix and Vent families of homeobox transcription factors. Following gastrulation, a subset of ventral mesoderm is specified to become hematopoietic stem cells. Key determinants of hematopoietic fate include the product of the zebrafish cloche gene and the basic helix-loop-helix transcription factor SCL. Future studies in Xenopus and zebrafish should reveal other critical factors in this developmental pathway.

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Species referenced: Xenopus
Genes referenced: tal1