Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-11983
Mech Dev 1999 Dec 01;891-2:141-50. doi: 10.1016/s0925-4773(99)00220-8.
Show Gene links Show Anatomy links

Zic1 regulates the patterning of vertebral arches in cooperation with Gli3.

Aruga J , Mizugishi K , Koseki H , Imai K , Balling R , Noda T , Mikoshiba K .


???displayArticle.abstract???
Skeletal abnormalities are described that appeared in Zic1-deficient mice. These mice show multiple abnormalities in the axial skeleton. The deformities are severe in the dorsal parts of the vertebrae, vertebral arches, but less so in the vertebral bodies (spina bifida occulta). The proximal ribs are deformed having ectopic processes. The abnormalities found in the vertebral arches can be traced back to disturbed segmental patterns of dorsal sclerotome. The Zic1/Gli3 double mutants showed severe abnormalities of vertebral arches not found in single mutants. The abnormalities in the vertebral arches were less severe in Zic1/Pax1 mutants than Zic1/Gli3 mutants, but significantly more pronounced than in Zic1 single mutants. The three genes may act synergistically in the development of the vertebral arches.

???displayArticle.pubmedLink??? 10559489
???displayArticle.link??? Mech Dev


Species referenced: Xenopus
Genes referenced: gli3 zic1