Nacken W (1997), Members of the AAA-gene family are involved in ...

XB-ART-15687

Biochim Biophys Acta 1997 Oct 09;13541:1-6.

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Members of the AAA-gene family are involved in early embryogenesis of vertebrates.

Nacken W .

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Here the nucleotide sequence of three cDNAs from Xenopus laevis are reported. The corresponding genes belong to the AAA-family of genes showing the strongest sequence homology to the human HIV-1 Tat binding protein 1 (TBP-1) and to the yeast SUG1 gene, respectively. Analysis of their expression pattern indicate that they are maternally stored in oocytes and involved in very early stages of vertebrate embryogenesis.

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Species referenced: Xenopus laevis
Genes referenced: nthl1 psmc3 psmc5

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	Fig. 1. Nucleotide sequence and the deduced amino acid sequence of the XTBP6 cDNA is shown.
	Fig. 2. Nucleotide sequence and the deduced amino acid sequence of the XTBP10 cDNA is shown.
	Fig. 3. Northern blot experiment. Total RNA from various Xenopus laevis tissues was loaded on a denaturing agarose gel: O= ovary, H= heart, G=gut, M=muscle, L=liver. CDNA-fragments of XTBP6 and XTBP10 were radiolabelled and used as probes as indicated. The XTBP10 probe crosshybridises with the XTBP6 message as seen in the ovary lane of the XTBP6 Nothern. Human GAPDH cDNA was used under reduced hybridisation stringency as control.
	Fig. 4. Nucleotide sequence and the deduced amino acid sequence of the XSUG1 cDNA is shown.
	Fig. 5. Northern blot experiment. Total RNA from various Xenopus laevis tissues was loaded on a denaturing agarose gel: O=ovary, G=gut, M=muscle, L=liver. CDNA of XSUG1 was radiolabelled and used as hybridisation probe as indicated. Human GAPDH cDNA was used under reduced hybridisation stringency as control.