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XB-ART-17282
Biochem Biophys Res Commun 1996 Dec 13;2292:363-9. doi: 10.1006/bbrc.1996.1811.
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Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligands for P2 purinoceptors.

Järlebark L , Erlandsson M , Uri A , King BF , Ziganshin AU , Johansson C , Heilbronn E .


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The role of extracellular ATP in vivo and the various cellular responses mediated by P2 purinoceptors have not yet been fully elucidated, in part depending on the lack of subtype-specific high affinity antagonists. Here we describe the synthesis of a new class of compounds, peptidyl derivatives of adenosine 5'-carboxylic acid, among which some have inhibitory effects in certain P2 purinoceptor-carrying biological systems, e.g., glioma and smooth muscle cell lines and isolated smooth muscle tissue preparations from guinea pig vas deferens and urinary bladder.

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Species referenced: Xenopus