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XB-ART-17331
Trends Biochem Sci 1996 Dec 01;2112:460-6.
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Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs.



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Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.

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References :
Brown, Why do protein kinase cascades have more than one level? 1997, Pubmed, Xenbase