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A recently described experimental system for analyzing the mode of action of a morphogen gradient involves the in situ hybridization of sectioned tissue constructs. In these constructs, a source of activin signaling induces the transcription of several mesodermal genes in blastula animal caps, according to the position of cells in a concentration gradient. New experiments show that activin-loaded beads emit a signal for only 2 hr and that the same cell can be induced to express different genes. We determine the position in the gradient and the time after the start of activin signaling at which early genes, including Mix1, Xpo, Xwnt8, Xchd, and Xlim1, are activated, relative to the previously tested genes Xbra and Xgsc.
Asashima,
Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.
1991, Pubmed,
Xenbase
Asashima,
Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.
1991,
Pubmed
,
Xenbase
Cho,
Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid.
1991,
Pubmed
,
Xenbase
Driever,
A gradient of bicoid protein in Drosophila embryos.
1988,
Pubmed
Fan,
Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway.
1995,
Pubmed
Ferguson,
Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo.
1992,
Pubmed
Green,
Growth factors as morphogens: do gradients and thresholds establish body plan?
1991,
Pubmed
,
Xenbase
Green,
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate.
1990,
Pubmed
,
Xenbase
Green,
Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.
1992,
Pubmed
,
Xenbase
Gurdon,
Direct and continuous assessment by cells of their position in a morphogen gradient.
1995,
Pubmed
Gurdon,
All components required for the eventual activation of muscle-specific actin genes are localized in the subequatorial region of an uncleaved amphibian egg.
1985,
Pubmed
,
Xenbase
Gurdon,
Activin signalling and response to a morphogen gradient.
1994,
Pubmed
,
Xenbase
Honig,
Positional signal transmission in the developing chick limb.
1981,
Pubmed
Johnson,
The long and short of hedgehog signaling.
1995,
Pubmed
Roelink,
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.
1995,
Pubmed
Rosa,
Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos.
1989,
Pubmed
,
Xenbase
Sasai,
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes.
1994,
Pubmed
,
Xenbase
Sato,
Localized and inducible expression of Xenopus-posterior (Xpo), a novel gene active in early frog embryos, encoding a protein with a 'CCHC' finger domain.
1991,
Pubmed
,
Xenbase
Smith,
Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.
1991,
Pubmed
,
Xenbase
Smith,
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center.
1991,
Pubmed
,
Xenbase
Taira,
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.
1992,
Pubmed
,
Xenbase
Thaller,
Identification and spatial distribution of retinoids in the developing chick limb bud.
,
Pubmed
Tickle,
Local application of retinoic acid to the limb bond mimics the action of the polarizing region.
1982,
Pubmed
