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J Membr Biol
1995 Nov 01;1481:51-6. doi: 10.1007/bf00234155.
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The expression of Na+/K(+)-ATPase beta-subunit cRNA injected into Xenopus oocytes is affected by coinjection with alpha-subunit cRNA.
Ueno S
,
Takeda K
,
Noguchi S
,
Izumi F
,
Kawamura M
.
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The cRNA for Torpedo californica Na+/K(+)-ATPase beta-subunit (cRNA beta) was injected into Xenopus oocytes alone or with the cRNA for the Na+/K(+)-ATPase alpha-subunit (cRNA alpha). When cRNA beta was injected alone, the amount of the beta-subunit that accumulated in oocytes increased with increasing amounts of injected cRNA beta. When cRNA beta and cRNA alpha were injected simultaneously, less beta-subunit accumulated than when cRNA beta was injected alone, whereas the Na+/K(+)-ATPase activity increased markedly. The decrease in the accumulation of the beta-subunit was dose-dependent upon the cRNA alpha. The mutant beta-subunit unable to assemble with the alpha-subunit accumulated in oocytes independently of cRNA alpha, suggesting that post-translational control mechanisms may serve to reduce the accumulation of the beta-subunit.
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