Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
1995 Nov 01;1421:5158-69. doi: 10.1002/j.1460-2075.1995.tb00200.x.
Show Gene links
Show Anatomy links
Expression of band 3 anion exchanger induces chloride current and taurine transport: structure-function analysis.
Fiévet B
,
Gabillat N
,
Borgese F
,
Motais R
.
???displayArticle.abstract???
Most, but not all, cell types release intracellular organic solutes (e.g. taurine) in response to cell swelling to achieve cell volume regulation. Although this efflux is blocked by classical inhibitors of the electroneutral anion exchanger band 3 (AE1), it is thought to involve an anion channel. The role of band 3 in volume-dependent taurine transport was determined by expressing, in Xenopus oocytes, band 3 from erythrocytes which do (trout) or do not (mouse) release taurine when swollen. AE1 of both species elicited anion exchange activity, but only trout band 3 showed chloride channel activity and taurine transport. Chimeras constructed from trout and mouse band 3 allowed the identification of some protein domains critically associated with channel activity and taurine transport. The data provide evidence that swelling-induced taurine movements occur via an anion channel which is dependent on, or controlled by, band 3. They suggest the involvement of proteins of the band 3 (AE) family in cell volume regulation.
Ackerman,
Hypotonicity activates a native chloride current in Xenopus oocytes.
1994, Pubmed,
Xenbase
Ackerman,
Hypotonicity activates a native chloride current in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Alper,
Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line.
1988,
Pubmed
Baroin,
A transient sodium-hydrogen exchange system induced by catecholamines in erythrocytes of rainbow trout, Salmo gairdneri.
1984,
Pubmed
Cabantchik,
Chemical probes for anion transporters of mammalian cell membranes.
1992,
Pubmed
Chomczynski,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
1987,
Pubmed
Church,
Genomic sequencing.
1984,
Pubmed
Dascal,
The use of Xenopus oocytes for the study of ion channels.
1987,
Pubmed
,
Xenbase
Demuth,
Cloning and structural characterization of a human non-erythroid band 3-like protein.
1986,
Pubmed
Fugelli,
Taurine transport associated with cell volume regulation in flounder erythrocytes under anisosmotic conditions.
1986,
Pubmed
Garcia,
Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates.
1989,
Pubmed
,
Xenbase
Garcia-Romeu,
Cell volume regulation by trout erythrocytes: characteristics of the transport systems activated by hypotonic swelling.
1991,
Pubmed
Gill,
Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.
1992,
Pubmed
Goldstein,
Volume-activated taurine efflux from skate erythrocytes: possible band 3 involvement.
1991,
Pubmed
Hardy,
Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.
1995,
Pubmed
Higgins,
Volume-activated chloride currents associated with the multidrug resistance P-glycoprotein.
1995,
Pubmed
Hoffmann,
Membrane mechanisms in volume and pH regulation in vertebrate cells.
1989,
Pubmed
Horio,
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.
1988,
Pubmed
Hübner,
Amino acid sequence of band-3 protein from rainbow trout erythrocytes derived from cDNA.
1992,
Pubmed
Humphreys,
Functional characterization and regulation by pH of murine AE2 anion exchanger expressed in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Huxtable,
Physiological actions of taurine.
1992,
Pubmed
Jackson,
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux.
1993,
Pubmed
Jentsch,
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Kirk,
Volume-regulatory taurine release from a human lung cancer cell line. Evidence for amino acid transport via a volume-activated chloride channel.
1993,
Pubmed
Kirk,
Transport of organic substrates via a volume-activated channel.
1992,
Pubmed
Knauf,
The relationship between anion exchange and net anion flow across the human red blood cell membrane.
1977,
Pubmed
Krapivinsky,
Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln.
1994,
Pubmed
,
Xenbase
Lambert,
Regulation of taurine transport in Ehrlich ascites tumor cells.
1993,
Pubmed
Lepke,
Mediation of inorganic anion transport by the hydrophobic domain of mouse erythroid band 3 protein expressed in oocytes of Xenopus laevis.
1992,
Pubmed
,
Xenbase
Motais,
Red cell volume regulation: the pivotal role of ionic strength in controlling swelling-dependent transport systems.
1991,
Pubmed
Musch,
Oligomeric forms of skate erythrocyte band 3. Effect of volume expansion.
1994,
Pubmed
Paulmichl,
New mammalian chloride channel identified by expression cloning.
1992,
Pubmed
,
Xenbase
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Sarkadi,
Activation of ion transport pathways by changes in cell volume.
1991,
Pubmed
Valverde,
Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein.
1992,
Pubmed
