Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Cell Biol
1993 Oct 01;1310:6479-89. doi: 10.1128/mcb.13.10.6479-6489.1993.
Show Gene links
Show Anatomy links
XrpFI, an amphibian transcription factor composed of multiple polypeptides immunologically related to the GA-binding protein alpha and beta subunits, is differentially expressed during Xenopus laevis development.
Marchioni M
,
Morabito S
,
Salvati AL
,
Beccari E
,
Carnevali F
.
???displayArticle.abstract???
XrpFI, first identified in the extract of Xenopus laevis oocyte nuclei, binds to a proximal sequence of the L14 ribosomal protein gene promoter. Its target sequence, 5'-TAACCGGAAGTTTGT-3', is required to fully activate the promoter, and the two G's of the central motif are essential for factor binding and transcriptional activation; our data also suggest that XrpFI may play a role in cap site positioning. The binding site of XrpFI is homologous to the sequence recognized by the family of ets genes. Antibodies specific for Ets-1 and Ets-2 proteins did not react with XrpFI, but those raised against the rat alpha and beta GA-binding proteins both supershifted the retarded bands formed by XrpFI. The Xenopus polypeptides related to GA-binding protein alpha interact with DNA both as monomers and as heterodimers associated with beta-related proteins. Oocyte nuclei contain multiple forms of alpha- and beta-related proteins: the alpha-like proteins remain throughout development, while the pattern of the beta species changes in the embryonic stages examined. beta-like proteins are undetectable in the cleavage period up to the neurula stage, but at later stages, when ribosomal protein genes are actively transcribed, two beta-related polypeptides reappear.
Baeuerle,
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor.
1988, Pubmed
Baeuerle,
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor.
1988,
Pubmed
Beccari,
Sequences coding for the ribosomal protein L14 in Xenopus laevis and Xenopus tropicalis; homologies in the 5' untranslated region are shared with other r-protein mRNAs.
1986,
Pubmed
,
Xenbase
Ben-David,
Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1.
1991,
Pubmed
Bhat,
Temporal and tissue-specific expression of mouse ets genes.
1987,
Pubmed
Brown,
Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins.
1992,
Pubmed
BROWN,
RNA SYNTHESIS DURING THE DEVELOPMENT OF XENOPUS LAEVIS, THE SOUTH AFRICAN CLAWED TOAD.
1964,
Pubmed
,
Xenbase
Burdett,
Characterization of the cDNA sequences of two Xenopus ets-2 proto-oncogenes.
1992,
Pubmed
,
Xenbase
Carnevali,
Nuclear factors specifically bind to upstream sequences of a Xenopus laevis ribosomal protein gene promoter.
1989,
Pubmed
,
Xenbase
Chen,
Requirement of ets-2 expression for Xenopus oocyte maturation.
1990,
Pubmed
,
Xenbase
Dumont,
Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
1972,
Pubmed
,
Xenbase
Dynan,
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins.
,
Pubmed
Gutman,
Nuclear targets for transcription regulation by oncogenes.
1991,
Pubmed
Gutman,
The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.
1990,
Pubmed
Hariharan,
Equipotent mouse ribosomal protein promoters have a similar architecture that includes internal sequence elements.
1989,
Pubmed
Hariharan,
Functional dissection of a mouse ribosomal protein promoter: significance of the polypyrimidine initiator and an element in the TATA-box region.
1990,
Pubmed
Karim,
The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence.
1990,
Pubmed
Klemsz,
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene.
1990,
Pubmed
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Lagna,
HrpF, a human sequence-specific DNA-binding protein homologous to XrpFI, a Xenopus laevis oocyte transcription factor.
1990,
Pubmed
,
Xenbase
Lai,
Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.
1992,
Pubmed
LaMarco,
Identification of Ets- and notch-related subunits in GA binding protein.
1991,
Pubmed
Leprince,
A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.
,
Pubmed
Maniatis,
Regulation of inducible and tissue-specific gene expression.
1987,
Pubmed
Matsui,
Multiple factors required for accurate initiation of transcription by purified RNA polymerase II.
1980,
Pubmed
Maxam,
Sequencing end-labeled DNA with base-specific chemical cleavages.
1980,
Pubmed
McKnight,
Transcriptional control signals of a eukaryotic protein-coding gene.
1982,
Pubmed
Nunn,
Tripartite structure of the avian erythroblastosis virus E26 transforming gene.
,
Pubmed
Nye,
Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif.
1992,
Pubmed
Pierandrei-Amaldi,
Expression of ribosomal-protein genes in Xenopus laevis development.
1982,
Pubmed
,
Xenbase
Ptashne,
Gene regulation by proteins acting nearby and at a distance.
,
Pubmed
Reddy,
The erg gene: a human gene related to the ets oncogene.
1987,
Pubmed
Reynolds,
Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region.
1985,
Pubmed
Scotto,
Positive and negative regulation of the gene for transcription factor IIIA in Xenopus laevis oocytes.
1989,
Pubmed
,
Xenbase
Stiegler,
Characterization of Xenopus laevis cDNA clones of the c-ets-1 proto-oncogene.
1990,
Pubmed
,
Xenbase
Thompson,
Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex.
1991,
Pubmed
Thompson,
cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.
1992,
Pubmed
Urness,
Molecular interactions within the ecdysone regulatory hierarchy: DNA binding properties of the Drosophila ecdysone-inducible E74A protein.
1990,
Pubmed
Virbasius,
Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.
1993,
Pubmed
Wang,
The acidic activator GAL4-AH can stimulate polymerase II transcription by promoting assembly of a closed complex requiring TFIID and TFIIA.
1992,
Pubmed
Wasylyk,
The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.
1991,
Pubmed
Wasylyk,
The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation.
1990,
Pubmed
Watson,
Mammalian ets-1 and ets-2 genes encode highly conserved proteins.
1988,
Pubmed
,
Xenbase
Wolff,
Isolation of two different c-ets-2 proto-oncogenes in Xenopus laevis.
1990,
Pubmed
,
Xenbase
Xin,
Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.
1992,
Pubmed
Yoganathan,
A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family.
1992,
Pubmed