Pohl BS et al. (2005), The Fox gene family in Xenopus laevis:FoxI2, Fo...

XB-ART-2234

Int J Dev Biol 2005 Jan 01;491:53-8. doi: 10.1387/ijdb.051977bp.

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The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development.

Pohl BS , Rössner A , Knöchel W .

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We here describe the sequences and expression patterns of three new Fox (fork head box) transcription factors in Xenopus laevis embryos. xlFoxI2, another member of subclass I, is maternally transcribed. Zygotic transcripts are first detected during neurulation and become localised to the dorsal part of epibranchial placodes. xlFoxM1 like xlFoxP1 are the first members of subclasses M and P described in Xenopus. Both genes are maternally expressed and transcripts are found during early cleavage stages in the animal blastomeres. xlFoxM1 is strongly upregulated during neurula stages and transcripts are localised in the neuroectoderm. Later, expression is found in the spinal cord, the rhombencephalon, the retina and in the branchial arches. xlFoxP1 is activated during organogenesis and is mainly expressed in the brain, head mesenchyme and in the splanchnic layer of the lateral plate mesoderm.

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Species referenced: Xenopus laevis
Genes referenced: foxi2 foxi4 foxi4.2 foxl2 foxm1 foxp1

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	Fig. 3. Whole mount in situ hybridisation of xlFoxI2. (A) 2-cell stage, animal view; (B) 4-cell stage, lateral view; (C) stage 35, the red lines denote sections shown in (D,E) which are transverse and horizontal sections respectively, through the dorsal epibranchial placodes; (F) stage 35 stained for xlFoxI1a; (G) stage 34 stained for xlFoxI1c. he, heart anlage; rh, rhombencephalon; I., II., III., first, second and third visceral pouches.
	Fig. 5. Whole mount in situ hybridisation of xlFoxM1. (A) 2-cell stage, lateral view; (B) stage 16, dorsal view, anterior to the bottom; (C) stage 19, anterior view; (D) stage 22, lateral view; (E) stage 26, dorsal view; (F) stage 35; in (D-F), anterior is to the right. Red lines in (F) denote sections shown in (G-I). (G) Transverse section revealing xlFoxM1 expression in the rhombencephalon; (H) transverse section demonstrating additional stain- ing of the branchial arches; (I) horizontal section of the head with staining of the retina, anterior is to the bottom. ba, branchial arches; le, lens; he, heart; pn, pronephros; rh, rhombencephalon.
	Fig. 6. Whole mount in situ hybridisation of xlFoxP1. (A) 8-cell stage, lateral view; (B) stage 31; (C) stage 35, red lines in (C) indicate the plane of sections shown in (E-G); (D) stage 41, (B-D) are lateral views; (E) horizontal section, anterior is to the bottom; (F,G) transverse sections, dorsal is on top. ep, epidermis; he, heart; hm, head mesenchyme; le, lens; me, mesencephalon; pn, pronephros; ve, brain ventricle.
	foxm1 (forkhead box M1 ) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 16, dorsal view, dorsal up.
	foxm1 (forkhead box M1 ) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 19, anterior view, dorsal up.
	foxm1 (forkhead box M1 ) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 22, lateral view, dorsal up, anterior left.
	foxm1 (forkhead box M1 ) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 26, dorsal view, anterior right.
	foxm1 (forkhead box M1) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 2 ( 2 cell), lateral view, animal hemisphere up.
	foxp1 [forkhead box P1] gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 4 (8 cells), lateral view, dorsal up.
	foxp1 (forkhead box P1) gene expression in Xenopus laevis embryo via in situ hybridization, NF stage 31, lateral view, dorsal up, anterior right.
	foxp1 [forkhead box P1] gene expression in Xenopus laevis embryo via in situ hybridization, NF stage 35, lateral view, head region only, dorsal up, anterior right.
	foxp1 (forkhead box P1) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 41, lateral view, dorsal up, anterior right, head and trunk region only.