Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Biol Cell
1993 Jan 01;41:7-20. doi: 10.1091/mbc.4.1.7.
Show Gene links
Show Anatomy links
Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.
Bruzzone R
,
Haefliger JA
,
Gimlich RL
,
Paul DL
.
???displayArticle.abstract???
The cellular distribution of connexin40 (Cx40), a newly cloned gap junction structural protein, was examined by immunofluorescence microscopy using two different specific anti-peptide antibodies. Cx40 was detected in the endothelium of muscular as well as elastic arteries in a punctate pattern consistent with the known distribution of gap junctions. However, it was not detected in other cells of the vascular wall. By contrast, Cx43, another connexin present in the cardiovascular system, was not detected in endothelial cells of muscular arteries but was abundant in the myocardium and aortic smooth muscle. We have tested the ability of these connexins to interact functionally. Cx40 was functionally expressed in pairs of Xenopus oocytes and induced the formation of intercellular channels with unique voltage dependence. Unexpectedly, communication did not occur when oocytes expressing Cx40 were paired with those expressing Cx43, although each could interact with a different connexin, Cx37, to form gap junction channels in paired oocytes. These findings indicate that establishment of intercellular communication can be spatially regulated by the selective expression of different connexins and suggest a mechanism that may operate to control the extent of communication between cells.
Baker,
Effects of oligo sequence and chemistry on the efficiency of oligodeoxyribonucleotide-mediated mRNA cleavage.
1990, Pubmed,
Xenbase
Baker,
Effects of oligo sequence and chemistry on the efficiency of oligodeoxyribonucleotide-mediated mRNA cleavage.
1990,
Pubmed
,
Xenbase
Barrio,
Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.
1991,
Pubmed
,
Xenbase
Bennett,
Gap junctions: new tools, new answers, new questions.
1991,
Pubmed
Bény,
Dye and electrical coupling of endothelial cells in situ.
1989,
Pubmed
Bény,
An electron-microscopic study of smooth muscle cell dye coupling in the pig coronary arteries. Role of gap junctions.
1992,
Pubmed
Beyer,
Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.
1989,
Pubmed
Beyer,
Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle.
1992,
Pubmed
Beyer,
Connexin43: a protein from rat heart homologous to a gap junction protein from liver.
1987,
Pubmed
Burt,
Single-channel events and gating behavior of the cardiac gap junction channel.
1988,
Pubmed
Chanson,
Extent and modulation of junctional communication between pancreatic acinar cells in vivo.
1991,
Pubmed
Dahl,
Expression of functional cell-cell channels from cloned rat liver gap junction complementary DNA.
1987,
Pubmed
,
Xenbase
Dermietzel,
Differential expression of three gap junction proteins in developing and mature brain tissues.
1989,
Pubmed
Ebihara,
Cloning and expression of a Xenopus embryonic gap junction protein.
1989,
Pubmed
,
Xenbase
Eghbali,
Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32.
1990,
Pubmed
Epstein,
A study of communication specificity between cells in culture.
1977,
Pubmed
Findlay,
The extent of dye-coupling between exocrine acinar cells of the mouse pancreas. The dye-coupled acinar unit.
1983,
Pubmed
Fishman,
Molecular characterization and functional expression of the human cardiac gap junction channel.
1990,
Pubmed
Giaume,
Voltage-clamp analysis of a crayfish rectifying synapse.
1987,
Pubmed
Gimlich,
Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos.
1990,
Pubmed
,
Xenbase
Gimlich,
Sequence and developmental expression of mRNA coding for a gap junction protein in Xenopus.
1988,
Pubmed
,
Xenbase
Goodenough,
Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions.
1988,
Pubmed
Haefliger,
Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
1992,
Pubmed
Hennemann,
Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung.
1992,
Pubmed
,
Xenbase
Hoh,
Molecular cloning and characterization of a new member of the gap junction gene family, connexin-31.
1991,
Pubmed
,
Xenbase
Kadle,
Tissue-specific distribution of differentially phosphorylated forms of Cx43.
1991,
Pubmed
Kalimi,
Communication compartments in the gastrulating mouse embryo.
1988,
Pubmed
Kam,
Communication compartments in hair follicles and their implication in differentiative control.
1992,
Pubmed
Kanter,
Cardiac myocytes express multiple gap junction proteins.
1992,
Pubmed
Krieg,
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.
1984,
Pubmed
,
Xenbase
Kumar,
Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein.
1986,
Pubmed
Lal,
Voltage-dependent gating and single-channel conductance of adult mammalian atrial gap junctions.
1992,
Pubmed
Larson,
Gap junction messenger RNA expression by vascular wall cells.
1990,
Pubmed
Lo,
Gap junctional communication in the post-implantation mouse embryo.
1979,
Pubmed
Meda,
In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells.
1991,
Pubmed
Methfessel,
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.
1986,
Pubmed
,
Xenbase
Michalke,
Communication between cells of different type.
1971,
Pubmed
Moore,
Characterization of gap junction channels in A7r5 vascular smooth muscle cells.
1991,
Pubmed
Moreno,
Phosphorylation shifts unitary conductance and modifies voltage dependent kinetics of human connexin43 gap junction channels.
1992,
Pubmed
Musil,
Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.
1990,
Pubmed
Nishi,
Developmental regulation of gap junction gene expression during mouse embryonic development.
1991,
Pubmed
Paul,
Molecular cloning of cDNA for rat liver gap junction protein.
1986,
Pubmed
Paul,
Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Pepper,
Coupling and connexin 43 expression in microvascular and large vessel endothelial cells.
1992,
Pubmed
Prentki,
Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion.
1987,
Pubmed
Risek,
Spatiotemporal expression of three gap junction gene products involved in fetomaternal communication during rat pregnancy.
1991,
Pubmed
Risek,
Modulation of gap junction transcript and protein expression during pregnancy in the rat.
1990,
Pubmed
Rubin,
Molecular analysis of voltage dependence of heterotypic gap junctions formed by connexins 26 and 32.
1992,
Pubmed
,
Xenbase
Segal,
Intracellular recording and dye transfer in arterioles during blood flow control.
1992,
Pubmed
Serras,
Communication compartments in the post-trochal ectoderm of the mollusc Lymnaea stagnalis.
1990,
Pubmed
Simionescu,
Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature.
1975,
Pubmed
Spray,
Equilibrium properties of a voltage-dependent junctional conductance.
1981,
Pubmed
,
Xenbase
Stutenkemper,
The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43.
1992,
Pubmed
Swenson,
Formation of gap junctions by expression of connexins in Xenopus oocyte pairs.
1989,
Pubmed
,
Xenbase
Swenson,
Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.
1990,
Pubmed
,
Xenbase
Valdimarsson,
Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development.
1991,
Pubmed
Veenstra,
Voltage-dependent gating of gap junction channels in embryonic chick ventricular cell pairs.
1990,
Pubmed
Wang,
Gating of mammalian cardiac gap junction channels by transjunctional voltage.
1992,
Pubmed
Werner,
Formation of hybrid cell-cell channels.
1989,
Pubmed
,
Xenbase
Willecke,
Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung.
1991,
Pubmed
,
Xenbase
Zhang,
Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA.
1989,
Pubmed
