Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-24594
Science 1991 Aug 30;2535023:1028-31.
Show Gene links Show Anatomy links

Identification of a site in glutamate receptor subunits that controls calcium permeability.

Hume RI , Dingledine R , Heinemann SF .


???displayArticle.abstract???
The neurotransmitter glutamate mediates excitatory synaptic transmission throughout the brain. A family of genes encoding subunits of the non-N-methyl-D-aspartate (non-NMDA) type of glutamate receptor has been cloned. Some combinations of these subunits assemble into receptors with a substantial permeability to calcium, whereas others do not. To investigate the structural features that control ion permeation through these ligand-gated channels, mutant receptor subunits with single-amino acid changes were constructed. Mutation of a certain amino acid that results in a net charge change (from glutamine to arginine or vice versa) alters both the current-voltage relation and the calcium permeability of non-NMDA receptors. A site has thus been identified that regulates the permeation properties of these glutamate receptors.

???displayArticle.pubmedLink??? 1653450
???displayArticle.link??? Science
???displayArticle.grants??? [+]