Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-24894
Science 1991 Apr 26;2525005:558-61.
Show Gene links Show Anatomy links

Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product.

Nebreda AR , Martin-Zanca D , Kaplan DR , Parada LF , Santos E .


???displayArticle.abstract???
The effect of nerve growth factor (NGF) was assessed in Xenopus oocytes expressing the human trk proto-oncogene product, p140prototrk. Oocytes injected with trk messenger RNA expressed polypeptides recognized by antibodies to the trk gene product. Exposure of these oocytes to nanomolar amounts of NGF resulted in specific surface binding of 125I-labeled NGF, tyrosine phosphorylation of p140prototrk, and meiotic maturation, as determined by germinal vesicle breakdown and maturation promoting factor (p34cdc2) kinase activation. Thus the trk proto-oncogene product can act as a receptor for NGF in a functionally productive manner.

???displayArticle.pubmedLink??? 1850550
???displayArticle.link??? Science


Species referenced: Xenopus laevis
Genes referenced: cdk1 ngf