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XB-ART-26666
Exp Cell Res 1989 Jul 01;1831:245-50.
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Evidence for a pertussis toxin-sensitive G protein involved in the control of meiotic reinitiation of Xenopus laevis oocytes.

Pellaz V , Schorderet-Slatkine S .


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Meiotic reinitiation of Xenopus laevis oocytes is induced in vitro by progesterone or insulin. The hormonal effect is inhibited in a dose-dependent manner by the injection of the A protomer of pertussis toxin (islet-activating protein, IAP) into the oocytes. This inhibition occurs only before the appearance of a maturation-promoting activity in the cytoplasm. Furthermore, injection of the toxin A protomer into recipient oocytes does not inhibit the induction of maturation obtained through injection of cytoplasm containing the maturation-promoting factor. The inhibition effect of the toxin A protomer is reversible with time. These results suggest that a pertussis-sensitive G protein is involved in intracellular signaling systems leading to the induction of MPF activity.

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Species referenced: Xenopus laevis
Genes referenced: ins