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Proc Natl Acad Sci U S A
1988 Oct 01;8519:7119-23.
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Transient administration of estradiol-17 beta establishes an autoregulatory loop permanently inducing estrogen receptor mRNA.
Barton MC
,
Shapiro DJ
.
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A single transient dose of estradiol-17 beta is sufficient to elicit the permanent induction of hepatic estrogen receptor mRNA, which is induced 18-fold (from 0.13 to 2.4 molecules per cell) and then remains fully induced for at least 125 days. In primary liver cultures, extremely low concentrations of estradiol-17 beta, which are below the Kd of the Xenopus laevis estrogen receptor, maintain persistent induction of estrogen receptor mRNA but not of estrogen-inducible vitellogenin mRNA. These data and the ability of the antiestrogen, hydroxytamoxifen, to reverse persistent induction of estrogen receptor mRNA, support a model in which transient doses of estradiol-17 beta induce the estrogen receptor and thereby establish an autoregulatory loop. The low levels of estradiol-17 beta normally circulating in male X. laevis and the elevated level of receptor provide sufficient hormone-receptor complex to permanently maintain the induced level of expression of the estrogen receptor gene. The permanent induction of the estrogen receptor may be the regulatory switch that results in the persistent expression of a recently identified class of proteins that exhibit long-term responses to estrogen.
Baker,
Rapid accumulation of vitellogenin messenger RNA during secondary estrogen stimulation of Xenopus laevis.
1978, Pubmed,
Xenbase
Baker,
Rapid accumulation of vitellogenin messenger RNA during secondary estrogen stimulation of Xenopus laevis.
1978,
Pubmed
,
Xenbase
Brock,
Estrogen regulates the absolute rate of transcription of the Xenopus laevis vitellogenin genes.
1983,
Pubmed
,
Xenbase
Brock,
Estrogen stabilizes vitellogenin mRNA against cytoplasmic degradation.
1983,
Pubmed
,
Xenbase
CHANG,
Genic control and hormonal reversal of sex differentiation in Xenopus.
1956,
Pubmed
,
Xenbase
Church,
Genomic sequencing.
1984,
Pubmed
Clark,
Nuclear retention of receptor-oestrogen complex and nuclear acceptor sites.
1976,
Pubmed
Danielsen,
The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.
1986,
Pubmed
Desplan,
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity.
,
Pubmed
Feinberg,
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
1984,
Pubmed
Giguère,
Identification of a new class of steroid hormone receptors.
1988,
Pubmed
Green,
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
,
Pubmed
Green,
A superfamily of potentially oncogenic hormone receptors.
,
Pubmed
Greene,
Sequence and expression of human estrogen receptor complementary DNA.
1986,
Pubmed
Haché,
Long-term effects of estrogen on avian liver: estrogen-inducible switch in expression of nuclear, hormone-binding proteins.
1987,
Pubmed
Hayward,
Activation of vitellogenin gene transcription is a direct response to estrogen in Xenopus laevis liver.
1982,
Pubmed
,
Xenbase
Hayward,
Induction of estrogen receptor and reversal of the nuclear/cytoplasmic receptor ratio during vitellogenin synthesis and withdrawal in Xenopus laevis.
1980,
Pubmed
,
Xenbase
Hiromi,
Regulation and function of the Drosophila segmentation gene fushi tarazu.
1987,
Pubmed
Hollenberg,
Primary structure and expression of a functional human glucocorticoid receptor cDNA.
1985,
Pubmed
Jordan,
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.
1977,
Pubmed
Kadonaga,
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain.
1987,
Pubmed
Katzenellenbogen,
Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells.
1984,
Pubmed
Klein-Hitpass,
An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells.
1986,
Pubmed
,
Xenbase
Kumar,
Functional domains of the human estrogen receptor.
1987,
Pubmed
McKearin,
Persistent estrogen induction of hepatic Xenopus laevis serum retinol binding protein mRNA.
1988,
Pubmed
,
Xenbase
McKearin,
Estrogen induces transcription of the Xenopus laevis serum retinol-binding protein gene.
1987,
Pubmed
,
Xenbase
Melton,
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
1984,
Pubmed
Miesfeld,
Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells.
,
Pubmed
Okret,
Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone.
1986,
Pubmed
Petkovich,
A human retinoic acid receptor which belongs to the family of nuclear receptors.
,
Pubmed
Read,
Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines.
1988,
Pubmed
Riegel,
Differential induction of hepatic estrogen receptor and vitellogenin gene transcription in Xenopus laevis.
1987,
Pubmed
,
Xenbase
Ringold,
Steroid hormone regulation of gene expression.
1985,
Pubmed
Robertson,
Retinoic acid receptor. Towards a biochemistry of morphogenesis.
,
Pubmed
Shapiro,
In vitro translation and estradiol-17beta induction of Xenopus laevis vitellogenin messenger RNA.
1976,
Pubmed
,
Xenbase
Tam,
Estrogen memory effect in human hepatocytes during repeated cell division without hormone.
1986,
Pubmed
Weiler,
The Xenopus laevis estrogen receptor: sequence homology with human and avian receptors and identification of multiple estrogen receptor messenger ribonucleic acids.
1987,
Pubmed
,
Xenbase
Wright,
Partial purification of estradiol receptor from Xenopus laevis liver and levels of receptor in relation to estradiol concentration.
1983,
Pubmed
,
Xenbase
Yamamoto,
Steroid receptor regulated transcription of specific genes and gene networks.
1985,
Pubmed
