Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-28507
FEBS Lett 1986 Oct 20;2071:121-6.
Show Gene links Show Anatomy links

The anti-oestrogen drug tamoxifen is an elongation inhibitor of eukaryotic protein biosynthesis.

Guille MJ , Arnstein HR .


???displayArticle.abstract???
The drug tamoxifen is widely used in the chemotherapy of breast cancer but its action is not explained completely by its anti-oestrogen properties. We now present evidence indicating that it is also a potent inhibitor of eukaryotic protein synthesis as demonstrated in Xenopus oocytes, intact reticulocytes and reticulocyte lysates. The inhibition affects general protein synthesis, is transient in oocytes and not reversed by oestrogen. The drug appears to act by inhibiting polypeptide chain elongation. This action of tamoxifen is independent of oestrogen receptors and may explain its therapeutic effectiveness in oestrogen-independent tumours.

???displayArticle.pubmedLink??? 3770187
???displayArticle.link??? FEBS Lett