Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
To clarify on what level of gene expression estrogen represses albumin synthesis in Xenopus hepatocytes, we have analyzed nuclear RNAs and the transcriptional rates in isolated nuclei. Since in nuclear RNA the quantity of albumin mRNA and its precursors does not change and the transcription remains constant during estrogen treatment, we conclude that a posttranscriptional control, possibly involving destabilization of cytoplasmic mRNA, is responsible for the repression of albumin synthesis by estrogen. This post-transcriptional control is in contrast to the well-known transcriptional induction of vitellogenin gene activity. The results can be reproduced in liver cube cultures thereby establishing that estrogen interferes directly with hepatic albumin synthesis. In these liver cube cultures albumin mRNA levels are reduced compared with the liver used to set up the culture whereas the transcription of the albumin genes is not influenced. This reveals another post-transcriptional control of hepatic albumin synthesis.
Bozzoni,
Xenopus laevis ribosomal protein genes: isolation of recombinant cDNA clones and study of the genomic organization.
1981, Pubmed,
Xenbase
Bozzoni,
Xenopus laevis ribosomal protein genes: isolation of recombinant cDNA clones and study of the genomic organization.
1981,
Pubmed
,
Xenbase
Brock,
Estrogen stabilizes vitellogenin mRNA against cytoplasmic degradation.
1983,
Pubmed
,
Xenbase
Brock,
Estrogen regulates the absolute rate of transcription of the Xenopus laevis vitellogenin genes.
1983,
Pubmed
,
Xenbase
Clayton,
Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes.
1983,
Pubmed
Derman,
Transcriptional control in the production of liver-specific mRNAs.
1981,
Pubmed
Felber,
Estradiol-induced accumulation of vitellogenin mRNA and secretion of vitellogenin in liver cultures of Xenopus.
1978,
Pubmed
,
Xenbase
Gerber-Huber,
In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated.
1983,
Pubmed
,
Xenbase
Gerber-Huber,
Estrogen induces tissue specific changes in the chromatin conformation of the vitellogenin genes in Xenopus.
1981,
Pubmed
,
Xenbase
Gorski,
Remodeling the estrogen receptor model.
1984,
Pubmed
Groudine,
Post-transcriptional regulation of the chicken thymidine kinase gene.
1984,
Pubmed
Hayward,
Induction of estrogen receptor and reversal of the nuclear/cytoplasmic receptor ratio during vitellogenin synthesis and withdrawal in Xenopus laevis.
1980,
Pubmed
,
Xenbase
Hayward,
A middle-affinity estrogen-specific binding protein in livers of vitellogenic and nonvitellogenic Xenopus laevis.
1981,
Pubmed
,
Xenbase
Hayward,
The role of estrogen receptor in Xenopus laevis vitellogenin gene expression.
1982,
Pubmed
,
Xenbase
Landes,
Hemoglobin switching in chickens. Is the switch initiated post-transcriptionally?
1982,
Pubmed
May,
Structure and evolution of the Xenopus laevis albumin genes.
1983,
Pubmed
,
Xenbase
May,
Estrogen dramatically decreases albumin mRNA levels and albumin synthesis in Xenopus laevis liver.
1982,
Pubmed
,
Xenbase
McKnight,
Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.
1979,
Pubmed
McMaster,
Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.
1977,
Pubmed
O'Malley,
The ovalbumin gene: organization, structure, transcription, and regulation.
1979,
Pubmed
O'Malley,
Steroid hormone action in eucaryotic cells.
1984,
Pubmed
Ryffel,
Quantitation of vitellogenin messenger RNA in the liver of male Xenopus toads during primary and secondary stimulation by estrogen.
1977,
Pubmed
,
Xenbase
Ryffel,
Identification, organization and processing intermediates of the putative precursors of Xenopus vitellogenin messenger RNA.
1980,
Pubmed
,
Xenbase
Searle,
Vitellogenin gene expression in male Xenopus hepatocytes during primary and secondary stimulation with estrogen in cell cultures.
1981,
Pubmed
,
Xenbase
Tata,
Selective steroid hormonal regulation of gene expression in multigene families.
1981,
Pubmed
Vannice,
Glucocorticoid-mediated induction of alpha 1-acid glycoprotein: evidence for hormone-regulated RNA processing.
1984,
Pubmed
Wahli,
Vitellogenin in Xenopus laevis is encoded in a small family of genes.
1979,
Pubmed
,
Xenbase
Wahli,
Vitellogenesis and the vitellogenin gene family.
1981,
Pubmed
,
Xenbase
Wangh,
Parenchymal cells purified from Xenopus liver and maintained in primary culture synthesize vitellogenin in response to estradiol-17 beta and serum albumin in response to dexamethasone.
1979,
Pubmed
,
Xenbase
Wangh,
Glucocorticoids act together with estrogens and thyroid hormones in regulating the synthesis and secretion of Xenopus vitellogenin, serum albumin, and fibrinogen.
1982,
Pubmed
,
Xenbase
Westley,
Xenopus laevis serum albumins are encoded in two closely related genes.
1981,
Pubmed
,
Xenbase
Williams,
Simultaneous analysis of conformation and transcription of A and B groups of vitellogenin genes in male and female Xenopus during primary and secondary activation by estrogen.
1983,
Pubmed
,
Xenbase
Wright,
Partial purification of estradiol receptor from Xenopus laevis liver and levels of receptor in relation to estradiol concentration.
1983,
Pubmed
,
Xenbase
