Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-30729
Proc Natl Acad Sci U S A 1982 Mar 01;795:1388-92.
Show Gene links Show Anatomy links

Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription.

Ciampi MS , Melton DA , Cortese R .


???displayArticle.abstract???
Point mutations have been introduced in vitro in a cloned nematode tRNAPro gene. Four different mutant clones altered in the DNA that codes for tRNAPro have been isolated. Studies on the expression of the mutant genes by microinjection into Xenopus oocyte nuclei reveal that their activities as transcription templates are reduced. The results show that DNA sequences that code for the extra arm and the stem of the T-psi-C-G arm of the tRNAPro have an important role in the initiation of tRNA gene transcription.

???displayArticle.pubmedLink??? 6951183
???displayArticle.pmcLink??? PMC345978
???displayArticle.link??? Proc Natl Acad Sci U S A


Genes referenced: mt-tr trna

References [+] :
Barnes, DNA sequence from the histidine operon control region: seven histidine codons in a row. 1978, Pubmed