XB-ART-31761
Cell Biol Int Rep
1979 Mar 01;32:183-8.
Show Gene links
Show Anatomy links
SV40 DNA injected into Xenopus oocyte nuclei is transcribed by RNA polymerase B.
???displayArticle.abstract???
SV40 DNA I. injected into Xenopus oocyte nuclei is transcribed. The SV40-specific RNA molecules migrate on sucrose gradients as do viral RNAs formed in infected green monkey cells but a variable proportion of RNA sequences complementary to SV40 DNA is also found in the light region of the gradients. All SV40-specific RNA species seem to be synthesized by RNA polymerase B as their synthesis is completely sensitive to low concentrations (0.1 microgram/ml) of alpha-amanitin. Concomittantly, the formation of SV40-specific proteins (tumor antigens) is inhibited by injecting alpha-amanitin together with the SV40 DNA.
???displayArticle.pubmedLink??? 222491