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Xenopus laevis 19S immunoglobulin. Ultrastructure and J chain isolation.
Hadji-Azimi I
,
Michea-Hamzehpour M
.
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Electron microscopy examination of the 19S immunoglobulin of Xenopus laevis revealed a hexameric structure with a central core. The molecules measured 360-430 A across the span of the arms and the average diameter of the central region was 140 A. A polypeptide, homologous to human J chain, was isolated by chromatography on DEAE-cellulose from the reduced and alkylated X. laevis hexameric macroglobulin. This polypeptide had a fast mobility in alkaline-urea gel electrophoresis, with distinct antigenicity, as compared to heavy and light chains. It shared common antigenic determinants with human J chain.
Chapuis,
Mechanism of IgM polymerization.
1974, Pubmed
Chapuis,
Mechanism of IgM polymerization.
1974,
Pubmed
Hadji-Azimi,
Structural studies of the Xenopus 19S immunoglobulin and 7S immunoglobulin and two immunoglobulin-like proteins.
1975,
Pubmed
,
Xenbase
Hadji-Azimi,
Studies on Xenopus laevis immunoglobulins.
1971,
Pubmed
,
Xenbase
Halpern,
Noval subunit in secretory IgA.
1970,
Pubmed
Kehoe,
Identification of "J" chain in a homogeneous canine IgA immunoglobulin.
1972,
Pubmed
Kobayashi,
Identification of J-chain in polymeric immunoglobulins from a variety of species by cross-reaction with rabbit antisera to human J-chain.
1973,
Pubmed
Mendez,
Structure of immunoglobulin A. Amino acid sequence of cysteine-containing peptides from the J chain.
1973,
Pubmed
Mestecky,
Site of attachment of J chain to human immunoglobulin M.
1974,
Pubmed
Mestecky,
Immunoglobulin M and secretory immunoglobulin A: presence of a common polypeptide chain different from light chains.
1971,
Pubmed
O'Daly,
Chemical and physicochemical studies of the component polypeptide chains of rabbit secretory immunoglobulin A.
1971,
Pubmed
Parkhouse,
Electron microscopic studies of mouse immunoglobulin M; structure and reconstitution following reduction.
1970,
Pubmed
Parkhouse,
Biosynthesis of immunoglobulin A (IgA) and immunoglobulin M (IgM). Control of polymerization by J chain.
1973,
Pubmed
Reisfeld,
Electrophoretic heterogeneity of polypeptide chains of specific antibodies.
1966,
Pubmed
Shelton,
Ultrastructure of the gamma M immunoglobulin-molecule.
1970,
Pubmed
Shelton,
The ultrastructure of carp (Cyprinus carpio) immunoglobulin: a tetrameric macroglobulin.
1970,
Pubmed
