Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-34512
Trends Biochem Sci 2006 Jul 01;317:402-10. doi: 10.1016/j.tibs.2006.05.004.
Show Gene links Show Anatomy links

The ATM-mediated DNA-damage response: taking shape.

Shiloh Y .


???displayArticle.abstract???
Cellular responses to DNA damage are crucial for maintaining homeostasis and preventing the development of cancer. Our understanding of the DNA-damage response has evolved: whereas previously the focus was on DNA repair, we now appreciate that the response to DNA lesions involves a complex, highly branched signaling network. Defects in this response lead to severely debilitating, cancer-predisposing "genomic instability syndromes". Double strand breaks (DSBs) in DNA are potent triggers of the DNA-damage response, which is why they are used to study this pathway. The chief transducer of the DSB signal is the nuclear protein kinase ataxia-telangiectasia mutated (ATM). Genetic, biochemical and structural studies have recently provided insights into the ATM-mediated DSB response, reshaping our view of this signaling pathway while raising new questions.

???displayArticle.pubmedLink??? 16774833
???displayArticle.link??? Trends Biochem Sci
???displayArticle.grants??? [+]

Species referenced: Xenopus
Genes referenced: atm