XB-ART-35246
Trends Mol Med
2006 Oct 01;1210:455-8. doi: 10.1016/j.molmed.2006.08.004.
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One ring to rule them all? Another cellular responsibility for PCNA.
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To prevent duplication or loss of genomic regions during DNA replication, it is essential that the entire genome is copied precisely once every S phase. Cells achieve this by mutually exclusive regulation of origin firing and licensing. A crucial protein that is involved in origin licensing is chromatin licensing and DNA replication factor 1 (CDT1) and, therefore, activity of this protein must be strictly controlled. Four recent articles have demonstrated that proliferating cell nuclear antigen (PCNA), an essential sliding clamp used in replication and DNA repair, has a crucial role in this process by mediating the proteasomal degradation of CDT1.
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Species referenced: Xenopus
Genes referenced: cdt1 pcna