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EMBO J
2007 May 02;269:2350-60. doi: 10.1038/sj.emboj.7601684.
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XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination.
Onai T
,
Matsuo-Takasaki M
,
Inomata H
,
Aramaki T
,
Matsumura M
,
Yakura R
,
Sasai N
,
Sasai Y
.
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In Xenopus, an asymmetric distribution of Wnt activity that follows cortical rotation in the fertilized egg leads to the dorsal-ventral (DV) axis establishment. However, how a clear DV polarity develops from the initial difference in Wnt activity still remains elusive. We report here that the Teashirt-class Zn-finger factor XTsh3 plays an essential role in dorsal determination by enhancing canonical Wnt signaling. Knockdown of the XTsh3 function causes ventralization in the Xenopus embryo. Both in vivo and in vitro studies show that XTsh3 substantially enhances Wnt signaling activity in a beta-catenin-dependent manner. XTsh3 cooperatively promotes the formation of a secondary axis on the ventral side when combined with weak Wnt activity, whereas XTsh3 alone has little axis-inducing ability. Furthermore, Wnt1 requires XTsh3 for its dorsalizing activity in vivo. Immunostaining and protein analyses indicate that XTsh3 is a nuclear protein that physically associates with beta-catenin and efficiently increases the level of beta-catenin in the nucleus. We discuss the role of XTsh3 as an essential amplifying factor of canonical Wnt signaling in embryonic dorsal determination.
Abe,
NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression.
2007,
Pubmed
Andrew,
Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes.
1994,
Pubmed
Bessa,
Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila.
2005,
Pubmed
Bessa,
Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt.
2002,
Pubmed
Brannon,
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.
1997,
Pubmed
,
Xenbase
Caubit,
Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt.
2000,
Pubmed
De Robertis,
Dorsal-ventral patterning and neural induction in Xenopus embryos.
2004,
Pubmed
,
Xenbase
De Robertis,
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
2000,
Pubmed
,
Xenbase
Fagotto,
Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin.
1998,
Pubmed
,
Xenbase
Fasano,
The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs.
1991,
Pubmed
Gallet,
Trunk-specific modulation of wingless signalling in Drosophila by teashirt binding to armadillo.
,
Pubmed
Gallet,
The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila.
1999,
Pubmed
Hamilton,
Difference in XTcf-3 dependency accounts for change in response to beta-catenin-mediated Wnt signalling in Xenopus blastula.
2001,
Pubmed
,
Xenbase
He,
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.
1995,
Pubmed
,
Xenbase
Heasman,
Patterning the early Xenopus embryo.
2006,
Pubmed
,
Xenbase
Henderson,
The ins and outs of APC and beta-catenin nuclear transport.
2002,
Pubmed
Hendriksen,
RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1.
2005,
Pubmed
,
Xenbase
Kazanskaya,
The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning.
2000,
Pubmed
,
Xenbase
Khokha,
Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structures.
2005,
Pubmed
,
Xenbase
Koebernick,
Xenopus Teashirt1 regulates posterior identity in brain and cranial neural crest.
2006,
Pubmed
,
Xenbase
Laugier,
A critical role of teashirt for patterning the ventral epidermis is masked by ectopic expression of tiptop, a paralog of teashirt in Drosophila.
2005,
Pubmed
Manfroid,
Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.
2004,
Pubmed
Mathies,
Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes.
1994,
Pubmed
Mizuseki,
SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos.
1998,
Pubmed
,
Xenbase
Molenaar,
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.
1996,
Pubmed
,
Xenbase
Moon,
From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus.
1998,
Pubmed
,
Xenbase
Moon,
The promise and perils of Wnt signaling through beta-catenin.
2002,
Pubmed
,
Xenbase
Morisato,
Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo.
1995,
Pubmed
Mosimann,
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
2006,
Pubmed
Onai,
Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling.
2004,
Pubmed
,
Xenbase
Osada,
Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis.
1999,
Pubmed
,
Xenbase
Peifer,
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.
2000,
Pubmed
Röder,
The role of the teashirt gene in trunk segmental identity in Drosophila.
1992,
Pubmed
Saller,
The transcriptional repressor Brinker antagonizes Wingless signaling.
2002,
Pubmed
Sasai,
The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements.
2004,
Pubmed
,
Xenbase
Sasai,
Ectodermal patterning in vertebrate embryos.
1997,
Pubmed
,
Xenbase
Sasai,
Requirement of FoxD3-class signaling for neural crest determination in Xenopus.
2001,
Pubmed
,
Xenbase
Schneider,
Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos.
1996,
Pubmed
,
Xenbase
Schohl,
A role for maternal beta-catenin in early mesoderm induction in Xenopus.
2003,
Pubmed
,
Xenbase
Schroeder,
Spatially regulated translation in embryos: asymmetric expression of maternal Wnt-11 along the dorsal-ventral axis in Xenopus.
1999,
Pubmed
,
Xenbase
Smith,
Mesoderm-inducing factors and mesodermal patterning.
1995,
Pubmed
,
Xenbase
Snider,
Inhibition of Tcf3 binding by I-mfa domain proteins.
2001,
Pubmed
,
Xenbase
Sokol,
Injected Wnt RNA induces a complete body axis in Xenopus embryos.
1991,
Pubmed
,
Xenbase
Städeli,
Transcription under the control of nuclear Arm/beta-catenin.
2006,
Pubmed
Tao,
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
2005,
Pubmed
,
Xenbase
van Eeden,
The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis.
1999,
Pubmed
Weaver,
Move it or lose it: axis specification in Xenopus.
2004,
Pubmed
,
Xenbase
Wu,
Proximal distal axis formation in the Drosophila leg: distinct functions of teashirt and homothorax in the proximal leg.
2000,
Pubmed
